Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002927681> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2002927681 endingPage "591" @default.
- W2002927681 startingPage "591" @default.
- W2002927681 abstract "SHORT- VERSUS LONG-ACTING ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS: Although ACE inhibitors are widely used in the treatment of hypertension, there are few data on trough:peak ratios and the data are contradictory. Part of the explanation for this lies in differences in pharmacological properties. Depending on the kinetics of elimination, the trough:peak ratio of short- and long-acting ACE inhibitors has to be evaluated according to a dose regimen of twice or once a day, respectively, and must take account of the dose used, since long-acting ACE inhibitors appear to have a dose-dependent trough:peak effect. Further explanations for the contradictory trough:peak ratios reported for ACE inhibitors include measurement methods (clinic blood pressure versus ambulatory monitoring) and study design. TROUGH:PEAK RATIO: Data from randomly allocated, placebo-controlled studies indicate that both the short-acting ACE inhibitors captopril and quinapril given twice a day and the long-acting ACE inhibitors enalapril, lisinopril, benazepril and cilazapril given once a day have an acceptable trough:peak ratio (> 50%). The evidence suggests that when chemically different ACE inhibitors with similar kinetics of elimination are administered at equipotent doses, similar trough:peak ratios are obtained." @default.
- W2002927681 created "2016-06-24" @default.
- W2002927681 creator A5069377475 @default.
- W2002927681 creator A5082044967 @default.
- W2002927681 creator A5085376285 @default.
- W2002927681 creator A5090440205 @default.
- W2002927681 date "1994-01-01" @default.
- W2002927681 modified "2023-10-18" @default.
- W2002927681 title "Trough" @default.
- W2002927681 doi "https://doi.org/10.1097/00004872-199412001-00018" @default.
- W2002927681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7707164" @default.
- W2002927681 hasPublicationYear "1994" @default.
- W2002927681 type Work @default.
- W2002927681 sameAs 2002927681 @default.
- W2002927681 citedByCount "5" @default.
- W2002927681 crossrefType "journal-article" @default.
- W2002927681 hasAuthorship W2002927681A5069377475 @default.
- W2002927681 hasAuthorship W2002927681A5082044967 @default.
- W2002927681 hasAuthorship W2002927681A5085376285 @default.
- W2002927681 hasAuthorship W2002927681A5090440205 @default.
- W2002927681 hasConcept C112705442 @default.
- W2002927681 hasConcept C126322002 @default.
- W2002927681 hasConcept C134018914 @default.
- W2002927681 hasConcept C139719470 @default.
- W2002927681 hasConcept C162324750 @default.
- W2002927681 hasConcept C27016395 @default.
- W2002927681 hasConcept C2775940317 @default.
- W2002927681 hasConcept C2776992270 @default.
- W2002927681 hasConcept C2777880890 @default.
- W2002927681 hasConcept C2779479957 @default.
- W2002927681 hasConcept C2779611605 @default.
- W2002927681 hasConcept C2781352967 @default.
- W2002927681 hasConcept C2910800852 @default.
- W2002927681 hasConcept C32239851 @default.
- W2002927681 hasConcept C71924100 @default.
- W2002927681 hasConcept C84393581 @default.
- W2002927681 hasConcept C98274493 @default.
- W2002927681 hasConceptScore W2002927681C112705442 @default.
- W2002927681 hasConceptScore W2002927681C126322002 @default.
- W2002927681 hasConceptScore W2002927681C134018914 @default.
- W2002927681 hasConceptScore W2002927681C139719470 @default.
- W2002927681 hasConceptScore W2002927681C162324750 @default.
- W2002927681 hasConceptScore W2002927681C27016395 @default.
- W2002927681 hasConceptScore W2002927681C2775940317 @default.
- W2002927681 hasConceptScore W2002927681C2776992270 @default.
- W2002927681 hasConceptScore W2002927681C2777880890 @default.
- W2002927681 hasConceptScore W2002927681C2779479957 @default.
- W2002927681 hasConceptScore W2002927681C2779611605 @default.
- W2002927681 hasConceptScore W2002927681C2781352967 @default.
- W2002927681 hasConceptScore W2002927681C2910800852 @default.
- W2002927681 hasConceptScore W2002927681C32239851 @default.
- W2002927681 hasConceptScore W2002927681C71924100 @default.
- W2002927681 hasConceptScore W2002927681C84393581 @default.
- W2002927681 hasConceptScore W2002927681C98274493 @default.
- W2002927681 hasIssue "Suppl" @default.
- W2002927681 hasLocation W20029276811 @default.
- W2002927681 hasLocation W20029276812 @default.
- W2002927681 hasOpenAccess W2002927681 @default.
- W2002927681 hasPrimaryLocation W20029276811 @default.
- W2002927681 hasRelatedWork W16949880 @default.
- W2002927681 hasRelatedWork W1967771310 @default.
- W2002927681 hasRelatedWork W1969470184 @default.
- W2002927681 hasRelatedWork W2002927681 @default.
- W2002927681 hasRelatedWork W2016709284 @default.
- W2002927681 hasRelatedWork W2036110989 @default.
- W2002927681 hasRelatedWork W2116134343 @default.
- W2002927681 hasRelatedWork W2402753037 @default.
- W2002927681 hasRelatedWork W2522552519 @default.
- W2002927681 hasRelatedWork W2738235036 @default.
- W2002927681 hasVolume "12" @default.
- W2002927681 isParatext "false" @default.
- W2002927681 isRetracted "false" @default.
- W2002927681 magId "2002927681" @default.
- W2002927681 workType "article" @default.