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- W2002938146 abstract "Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) have a unique brain distribution, which has been historically defined by (3)H-radiolabeled kainate binding. Compared with recombinant KARs expressed in heterologous cells, synaptic KARs exhibit characteristically slow rise-time and decay kinetics. However, the mechanisms responsible for these distinct KAR properties remain unclear. We found that both the high-affinity binding pattern in the mouse brain and the channel properties of native KARs are determined by the KAR auxiliary subunit Neto1. Through modulation of agonist binding affinity and off-kinetics of KARs, but not trafficking of KARs, Neto1 determined both the KAR high-affinity binding pattern and the distinctively slow kinetics of postsynaptic KARs. By regulating KAR excitatory postsynaptic current kinetics, Neto1 can control synaptic temporal summation, spike generation and fidelity." @default.
- W2002938146 created "2016-06-24" @default.
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- W2002938146 date "2011-05-29" @default.
- W2002938146 modified "2023-10-16" @default.
- W2002938146 title "Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1" @default.
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- W2002938146 doi "https://doi.org/10.1038/nn.2837" @default.
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