Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002975202> ?p ?o ?g. }
- W2002975202 abstract "As a ubiquitous environmental organism that is occasionally part of the human flora, Pseudomonas aeruginosa could pose a health hazard for the immunocompromised astronauts during long-term missions. Therefore, insights into the behaviour of P. aeruginosa under spaceflight conditions were gained using two spaceflight-analogue culture systems: the rotating wall vessel (RWV) and the random position machine (RPM). Microarray analysis of P. aeruginosa PAO1 grown in the low shear modelled microgravity (LSMMG) environment of the RWV, compared with the normal gravity control (NG), revealed an apparent regulatory role for the alternative sigma factor AlgU (RpoE-like). Accordingly, P. aeruginosa cultured in LSMMG exhibited increased alginate production and upregulation of AlgU-controlled transcripts, including those encoding stress-related proteins. The LSMMG increased heat and oxidative stress resistance and caused a decrease in the oxygen transfer rate of the culture. This study also showed the involvement of the RNA-binding protein Hfq in the LSMMG response, consistent with its previously identified role in the Salmonella LSMMG and spaceflight response. The global transcriptional response of P. aeruginosa grown in the RPM was highly similar to that in NG. Fluid mixing was assessed in both systems and is believed to be a pivotal factor contributing to transcriptional differences between RWV- and RPM-grown P. aeruginosa. This study represents the first step towards the identification of virulence mechanisms of P. aeruginosa activated in response to spaceflight-analogue conditions, and could direct future research regarding the risk assessment and prevention of Pseudomonas infections during spaceflight and in immunocompromised patients." @default.
- W2002975202 created "2016-06-24" @default.
- W2002975202 creator A5012748720 @default.
- W2002975202 creator A5043030141 @default.
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- W2002975202 creator A5072981411 @default.
- W2002975202 creator A5075362321 @default.
- W2002975202 date "2010-04-01" @default.
- W2002975202 modified "2023-10-06" @default.
- W2002975202 title "Response of<i>Pseudomonas aeruginosa</i>PAO1 to low shear modelled microgravity involves AlgU regulation" @default.
- W2002975202 cites W1509847467 @default.
- W2002975202 cites W1517198674 @default.
- W2002975202 cites W1529940414 @default.
- W2002975202 cites W1595768312 @default.
- W2002975202 cites W1652585490 @default.
- W2002975202 cites W1757304708 @default.
- W2002975202 cites W1829890286 @default.
- W2002975202 cites W1853571779 @default.
- W2002975202 cites W1894518824 @default.
- W2002975202 cites W1901233028 @default.
- W2002975202 cites W1918080119 @default.
- W2002975202 cites W1955670445 @default.
- W2002975202 cites W1962097363 @default.
- W2002975202 cites W1967924074 @default.
- W2002975202 cites W1968252808 @default.
- W2002975202 cites W1969581053 @default.
- W2002975202 cites W1970221893 @default.
- W2002975202 cites W1977222691 @default.
- W2002975202 cites W1985692996 @default.
- W2002975202 cites W1989840431 @default.
- W2002975202 cites W1991369801 @default.
- W2002975202 cites W1992788484 @default.
- W2002975202 cites W2002260209 @default.
- W2002975202 cites W2012825558 @default.
- W2002975202 cites W2030308486 @default.
- W2002975202 cites W2030589189 @default.
- W2002975202 cites W2043375105 @default.
- W2002975202 cites W2044467224 @default.
- W2002975202 cites W2044913844 @default.
- W2002975202 cites W2052675415 @default.
- W2002975202 cites W2056592058 @default.
- W2002975202 cites W2068846358 @default.
- W2002975202 cites W2069409923 @default.
- W2002975202 cites W2070456988 @default.
- W2002975202 cites W2073845634 @default.
- W2002975202 cites W2081098333 @default.
- W2002975202 cites W2081170889 @default.
- W2002975202 cites W2083960671 @default.
- W2002975202 cites W2085058509 @default.
- W2002975202 cites W2087602424 @default.
- W2002975202 cites W2093584479 @default.
- W2002975202 cites W2097012953 @default.
- W2002975202 cites W2099940763 @default.
- W2002975202 cites W2103039114 @default.
- W2002975202 cites W2103083186 @default.
- W2002975202 cites W2103615189 @default.
- W2002975202 cites W2103753441 @default.
- W2002975202 cites W2104104407 @default.
- W2002975202 cites W2104191189 @default.
- W2002975202 cites W2104507655 @default.
- W2002975202 cites W2105264550 @default.
- W2002975202 cites W2106418531 @default.
- W2002975202 cites W2107277218 @default.
- W2002975202 cites W2109225133 @default.
- W2002975202 cites W2110035347 @default.
- W2002975202 cites W2110065044 @default.
- W2002975202 cites W2110488887 @default.
- W2002975202 cites W2114120528 @default.
- W2002975202 cites W2114769323 @default.
- W2002975202 cites W2115368037 @default.
- W2002975202 cites W2115390850 @default.
- W2002975202 cites W2116192644 @default.
- W2002975202 cites W2116904877 @default.
- W2002975202 cites W2117805957 @default.
- W2002975202 cites W2118342782 @default.
- W2002975202 cites W2118343646 @default.
- W2002975202 cites W2120865735 @default.
- W2002975202 cites W2121852245 @default.
- W2002975202 cites W2122703438 @default.
- W2002975202 cites W2123818413 @default.
- W2002975202 cites W2127060683 @default.
- W2002975202 cites W2131635947 @default.
- W2002975202 cites W2137856862 @default.
- W2002975202 cites W2139465744 @default.
- W2002975202 cites W2141563578 @default.
- W2002975202 cites W2141873437 @default.
- W2002975202 cites W2143279090 @default.
- W2002975202 cites W2146286718 @default.
- W2002975202 cites W2147498477 @default.
- W2002975202 cites W2148471158 @default.
- W2002975202 cites W2150264499 @default.
- W2002975202 cites W2153842751 @default.
- W2002975202 cites W2155588400 @default.
- W2002975202 cites W2155954664 @default.
- W2002975202 cites W2156106908 @default.
- W2002975202 cites W2159645284 @default.
- W2002975202 cites W2161767713 @default.
- W2002975202 cites W2163447197 @default.