FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002986019> ?p ?o ?g. }

• W2002986019 endingPage "14" @default.
• W2002986019 startingPage "6" @default.
• W2002986019 abstract "There is increasing interest in the role of infections in atherothrombotic conditions. In particular, bacteria, notably those of oral origin, have been shown to activate platelets using a variety of mechanisms. Previous studies have shown that S. sanguinis strain 2017-78 induces platelet aggregation which requires the presence of both vWF and IgG. This aggregation is accompanied by the consecutive phosphorylation/desphosphorylation/rephosphorylation of several signalling proteins. The first two phases are thromboxane-dependent whereas the rephosphorylation phase is mediated by engagement of the αIIbβ3 integrin. Here signalling events, specifically the potential role of MAP kinases, associated with S. sanguinis strain 2017-78-induced platelet activation have been further examined using an immunoblotting approach. The addition of S. sanguinis strain 2017-78 caused a similar triphasic phosphorylation profile of the platelet MAP kinase Erk2 to that seen with other phosphoproteins. Pretreatment with aspirin or RGDS did not affect 2017-78-induced Erk2 phosphorylation or desphosphorylation but both inhibited the rephosphorylation phase. In contrast the level of 2017-78-induced platelet MAP kinase p38 phosphorylation remained at an elevated level, and this was unaffected by aspirin. Similarly, 2017-78-induced cPLA2 phosphorylation remained above basal levels during the aggregation process. The p38 inhibitor SB203580 inhibited S. sanguinis-induced aggregation with no effect on the phosphorylation of either p38 or cPLA2. Thus the current study demonstrates the activation of both the Erk2 and p38 forms of MAP kinases, and of cPLA2, in platelets stimulated with S. sanguinis strain 2017-78, and is consistent with a role for Erk2, but not for p38, in the cPLA2 phosphorylation in response to S. sanguinis." @default.
• W2002986019 created "2016-06-24" @default.
• W2002986019 creator A5018837258 @default.
• W2002986019 creator A5026807241 @default.
• W2002986019 creator A5063276445 @default.
• W2002986019 date "2012-02-28" @default.
• W2002986019 modified "2023-10-17" @default.
• W2002986019 title "Platelet activation by<i>Streptococcus sanguinis</i>is accompanied by MAP kinase phosphorylation" @default.
• W2002986019 cites W131135156 @default.
• W2002986019 cites W1502206260 @default.
• W2002986019 cites W1507880759 @default.
• W2002986019 cites W1888911165 @default.
• W2002986019 cites W1962878214 @default.
• W2002986019 cites W1966570390 @default.
• W2002986019 cites W1968389268 @default.
• W2002986019 cites W1969886626 @default.
• W2002986019 cites W1975495359 @default.
• W2002986019 cites W1982474751 @default.
• W2002986019 cites W1985888026 @default.
• W2002986019 cites W1986438546 @default.
• W2002986019 cites W2000343242 @default.
• W2002986019 cites W2000854529 @default.
• W2002986019 cites W2003760989 @default.
• W2002986019 cites W2005714449 @default.
• W2002986019 cites W2006834114 @default.
• W2002986019 cites W2007842234 @default.
• W2002986019 cites W2014492932 @default.
• W2002986019 cites W2015791855 @default.
• W2002986019 cites W2020746449 @default.
• W2002986019 cites W2021284850 @default.
• W2002986019 cites W2021511409 @default.
• W2002986019 cites W2031056943 @default.
• W2002986019 cites W2041183642 @default.
• W2002986019 cites W2046589593 @default.
• W2002986019 cites W2049351087 @default.
• W2002986019 cites W2051897066 @default.
• W2002986019 cites W2053465902 @default.
• W2002986019 cites W2056945159 @default.
• W2002986019 cites W2062562302 @default.
• W2002986019 cites W2072945073 @default.
• W2002986019 cites W2076309204 @default.
• W2002986019 cites W2078811306 @default.
• W2002986019 cites W2080822958 @default.
• W2002986019 cites W2096610614 @default.
• W2002986019 cites W2102966538 @default.
• W2002986019 cites W2103205445 @default.
• W2002986019 cites W2108349218 @default.
• W2002986019 cites W2114210350 @default.
• W2002986019 cites W2115137085 @default.
• W2002986019 cites W2116607177 @default.
• W2002986019 cites W2126953591 @default.
• W2002986019 cites W2139769012 @default.
• W2002986019 cites W2149177924 @default.
• W2002986019 cites W2150345049 @default.
• W2002986019 cites W2159006716 @default.
• W2002986019 cites W2166567023 @default.
• W2002986019 cites W2168098737 @default.
• W2002986019 cites W2170474721 @default.
• W2002986019 cites W4252463170 @default.
• W2002986019 cites W98059712 @default.
• W2002986019 doi "https://doi.org/10.3109/09537104.2012.661105" @default.
• W2002986019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22372533" @default.
• W2002986019 hasPublicationYear "2012" @default.
• W2002986019 type Work @default.
• W2002986019 sameAs 2002986019 @default.
• W2002986019 citedByCount "5" @default.
• W2002986019 countsByYear W20029860192013 @default.
• W2002986019 countsByYear W20029860192014 @default.
• W2002986019 countsByYear W20029860192015 @default.
• W2002986019 countsByYear W20029860192017 @default.
• W2002986019 crossrefType "journal-article" @default.
• W2002986019 hasAuthorship W2002986019A5018837258 @default.
• W2002986019 hasAuthorship W2002986019A5026807241 @default.
• W2002986019 hasAuthorship W2002986019A5063276445 @default.
• W2002986019 hasConcept C11960822 @default.
• W2002986019 hasConcept C132149769 @default.
• W2002986019 hasConcept C184235292 @default.
• W2002986019 hasConcept C185592680 @default.
• W2002986019 hasConcept C203014093 @default.
• W2002986019 hasConcept C2777867728 @default.
• W2002986019 hasConcept C3018697912 @default.
• W2002986019 hasConcept C51551487 @default.
• W2002986019 hasConcept C523546767 @default.
• W2002986019 hasConcept C54355233 @default.
• W2002986019 hasConcept C58123911 @default.
• W2002986019 hasConcept C86803240 @default.
• W2002986019 hasConcept C89560881 @default.
• W2002986019 hasConcept C95444343 @default.
• W2002986019 hasConcept C97029542 @default.
• W2002986019 hasConceptScore W2002986019C11960822 @default.
• W2002986019 hasConceptScore W2002986019C132149769 @default.
• W2002986019 hasConceptScore W2002986019C184235292 @default.
• W2002986019 hasConceptScore W2002986019C185592680 @default.
• W2002986019 hasConceptScore W2002986019C203014093 @default.
• W2002986019 hasConceptScore W2002986019C2777867728 @default.
• W2002986019 hasConceptScore W2002986019C3018697912 @default.
• W2002986019 hasConceptScore W2002986019C51551487 @default.
• W2002986019 hasConceptScore W2002986019C523546767 @default.

• next