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• W2003000734 abstract "Erythromycin A is a potent antibiotic long-recognized as a therapeutic option for bacterial infections. The soil-dwelling bacterium Saccharopolyspora erythraea natively produces erythromycin A from a 55 kb gene cluster composed of three large polyketide synthase genes (each ∼10 kb) and 17 additional genes responsible for deoxysugar biosynthesis, macrolide tailoring, and resistance. In this study, the erythromycin A gene cluster was systematically transferred from S. erythraea to E. coli for reconstituted biosynthesis, with titers reaching 10 mg/l. Polyketide biosynthesis was then modified to allow the production of two erythromycin analogs. Success establishes E. coli as a viable option for the heterologous production of erythromycin A and more broadly as a platform for the directed production of erythromycin analogs." @default.
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• W2003000734 date "2010-11-01" @default.
• W2003000734 modified "2023-10-17" @default.
• W2003000734 title "Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous Host" @default.
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• W2003000734 doi "https://doi.org/10.1016/j.chembiol.2010.09.013" @default.
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