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• W2003007246 abstract "Abstract Calcium-pyrophosphate-nucleotide precipitates have been formed in vitro with a composition which is essentially identical to that reported for the dense bodies (storage vesicles) of human platelets. The solution composition and effect of pH on precipitate formation, as well as the dissolution behavior and degree of protonation of the various species, were determined. The precipitates have a similar composition and form equally well at pH 5.7 or 7.4, or with various monovalent counter ions in the starting solutions. In all cases, the adenine nucleotides appear to be associated with fewer protons than the corresponding species in free solution, and all precipitate components can exchange or dissolve rapidly unless the precipitate is maintained in a solution relatively rich in calcium and adenine nucleotides. These precipitates may serve as useful models for examining the relative contributions of the dense-body membrane and core constituents to the uptake and storage of biogenic amines by human platelets." @default.
• W2003007246 created "2016-06-24" @default.
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• W2003007246 date "1981-10-01" @default.
• W2003007246 modified "2023-09-27" @default.
• W2003007246 title "Preparation and characterization of synthetic models for the dense bodies of human platelets" @default.
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• W2003007246 doi "https://doi.org/10.1016/0143-4160(81)90005-1" @default.
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