FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003007957> ?p ?o ?g. }

• W2003007957 endingPage "413" @default.
• W2003007957 startingPage "407" @default.
• W2003007957 abstract "Pulmonary embolism (PE) causes pulmonary hypertension by mechanical obstruction and constriction of non-obstructed vasculature. We tested if experimental PE impairs pulmonary vascular endothelium-dependent dilation via activation of arginase II. Experimental PE was induced in male Sprague–Dawley rats by infusing 25 μm microspheres in the right jugular vein, producing moderate pulmonary hypertension. Shams received vehicle injection. Pulmonary arterial rings were isolated after 18 h and isometric tensions were determined. Dilations were induced with acetylcholine, calcium ionophore A23187 or nitroglycerin (NTG) in pre-contracted rings (phenylephrine). Protein expression was assessed by Western blot and immunohistochemistry. Arginase activity was inhibited by intravenous infusion of Nw-hydroxy-nor-l-arginine (nor-NOHA). l-Arginine supplementation was also given. Endothelium-dependent dilation responses were significantly reduced in PE vs. vehicle-treated animals (ACh: 50 ± 9% vs. 93 ± 3%; A23187: 19 ± 7% vs. 85 ± 7%, p < 0.05), while endothelium-independent dilations (NTG) were unchanged. Endothelial nitric oxide synthase (eNOS) protein content was unchanged by PE. Expression of arginase II increased 4.5-fold and immunohistochemistry revealed increased arginase II staining. Nor-NOHA treatment and l-arginine supplementation significantly improved pulmonary artery ring endothelium-dependent dilation in PE (ACh: 58 ± 6% PE, 88 ± 6% PE + nor-NOHA, 84 ± 4% PE + l-arginine). Experimental PE impairs endothelium-dependent pulmonary artery dilation, while endothelium-independent dilation remains unchanged. The data support the conclusion that up-regulation of arginase II protein expression contributes to pulmonary artery endothelial dysfunction in this model of experimental PE." @default.
• W2003007957 created "2016-06-24" @default.
• W2003007957 creator A5023573470 @default.
• W2003007957 creator A5060750580 @default.
• W2003007957 creator A5078351702 @default.
• W2003007957 creator A5083545977 @default.
• W2003007957 date "2011-08-01" @default.
• W2003007957 modified "2023-09-25" @default.
• W2003007957 title "Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism" @default.
• W2003007957 cites W1971110044 @default.
• W2003007957 cites W1988378971 @default.
• W2003007957 cites W1992705944 @default.
• W2003007957 cites W1996179004 @default.
• W2003007957 cites W1996295305 @default.
• W2003007957 cites W2012026140 @default.
• W2003007957 cites W2015156318 @default.
• W2003007957 cites W2016083220 @default.
• W2003007957 cites W2025994995 @default.
• W2003007957 cites W2026730383 @default.
• W2003007957 cites W2027365234 @default.
• W2003007957 cites W2033036990 @default.
• W2003007957 cites W2033306348 @default.
• W2003007957 cites W2036828118 @default.
• W2003007957 cites W2040241546 @default.
• W2003007957 cites W2048142078 @default.
• W2003007957 cites W2051486634 @default.
• W2003007957 cites W2059068788 @default.
• W2003007957 cites W2065114932 @default.
• W2003007957 cites W2065418097 @default.
• W2003007957 cites W2081966802 @default.
• W2003007957 cites W2085843772 @default.
• W2003007957 cites W2091984792 @default.
• W2003007957 cites W2107332424 @default.
• W2003007957 cites W2109708615 @default.
• W2003007957 cites W2114823942 @default.
• W2003007957 cites W2116905957 @default.
• W2003007957 cites W2118154607 @default.
• W2003007957 cites W2120968095 @default.
• W2003007957 cites W2125031388 @default.
• W2003007957 cites W2136055847 @default.
• W2003007957 cites W2142308786 @default.
• W2003007957 cites W2143199174 @default.
• W2003007957 cites W2156537912 @default.
• W2003007957 cites W2158421877 @default.
• W2003007957 cites W2167130644 @default.
• W2003007957 cites W2170719548 @default.
• W2003007957 cites W3016174875 @default.
• W2003007957 cites W3023919040 @default.
• W2003007957 cites W4231702115 @default.
• W2003007957 doi "https://doi.org/10.1016/j.pupt.2011.01.009" @default.
• W2003007957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21281730" @default.
• W2003007957 hasPublicationYear "2011" @default.
• W2003007957 type Work @default.
• W2003007957 sameAs 2003007957 @default.
• W2003007957 citedByCount "15" @default.
• W2003007957 countsByYear W20030079572012 @default.
• W2003007957 countsByYear W20030079572013 @default.
• W2003007957 countsByYear W20030079572015 @default.
• W2003007957 countsByYear W20030079572016 @default.
• W2003007957 countsByYear W20030079572017 @default.
• W2003007957 countsByYear W20030079572018 @default.
• W2003007957 countsByYear W20030079572019 @default.
• W2003007957 countsByYear W20030079572020 @default.
• W2003007957 countsByYear W20030079572021 @default.
• W2003007957 countsByYear W20030079572022 @default.
• W2003007957 crossrefType "journal-article" @default.
• W2003007957 hasAuthorship W2003007957A5023573470 @default.
• W2003007957 hasAuthorship W2003007957A5060750580 @default.
• W2003007957 hasAuthorship W2003007957A5078351702 @default.
• W2003007957 hasAuthorship W2003007957A5083545977 @default.
• W2003007957 hasConcept C120770815 @default.
• W2003007957 hasConcept C126322002 @default.
• W2003007957 hasConcept C134018914 @default.
• W2003007957 hasConcept C164007495 @default.
• W2003007957 hasConcept C185592680 @default.
• W2003007957 hasConcept C2776992346 @default.
• W2003007957 hasConcept C2777468819 @default.
• W2003007957 hasConcept C2777622882 @default.
• W2003007957 hasConcept C2777952589 @default.
• W2003007957 hasConcept C2778326061 @default.
• W2003007957 hasConcept C2780930700 @default.
• W2003007957 hasConcept C2780940725 @default.
• W2003007957 hasConcept C42219234 @default.
• W2003007957 hasConcept C515207424 @default.
• W2003007957 hasConcept C519581460 @default.
• W2003007957 hasConcept C55493867 @default.
• W2003007957 hasConcept C71924100 @default.
• W2003007957 hasConcept C84393581 @default.
• W2003007957 hasConceptScore W2003007957C120770815 @default.
• W2003007957 hasConceptScore W2003007957C126322002 @default.
• W2003007957 hasConceptScore W2003007957C134018914 @default.
• W2003007957 hasConceptScore W2003007957C164007495 @default.
• W2003007957 hasConceptScore W2003007957C185592680 @default.
• W2003007957 hasConceptScore W2003007957C2776992346 @default.
• W2003007957 hasConceptScore W2003007957C2777468819 @default.
• W2003007957 hasConceptScore W2003007957C2777622882 @default.
• W2003007957 hasConceptScore W2003007957C2777952589 @default.
• W2003007957 hasConceptScore W2003007957C2778326061 @default.

• next