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- W2003008889 abstract "A series of tartronic acid analogs of a non-peptide RGD mimetic were prepared and evaluated both for antagonism of the vitronectin receptor and for affinity to hydroxyapatite, the main inorganic component of bone matrix. The hydroxy bis acid unit was found to be optimal for both receptor binding and hydroxyapatite affinity, while the N-terminus affected only receptor binding affinity. Keywords: Arginine-Glycine-Aspartic Acid (rgd), vitronectin receptor, osteoporosis, tetracycline, aminotriazole, palladium-catalyzed coupling reactions, hydroxyapatite" @default.
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- W2003008889 date "2005-05-01" @default.
- W2003008889 modified "2023-09-27" @default.
- W2003008889 title "Preliminary In vitro Results Indicating Tartronic Acids as Aspartic Acid Mimetics in Vitronectin Receptor Antagonists: Evidence for Increased Hydroxyapatite Affinity" @default.
- W2003008889 doi "https://doi.org/10.2174/1570180053765110" @default.
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