Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003011648> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2003011648 endingPage "227" @default.
- W2003011648 startingPage "218" @default.
- W2003011648 abstract "Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague–Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM) for 4 weeks. Thein situsuperfused cremaster muscle was prepared for observation by television microscopy. Changes in the microvessel diameter in response to acetylcholine, iloprost, cholera toxin, forskolin, or sodium nitroprusside were measured with a video micrometer. Arteriolar responses to each of the agonists were decreased under both HS and HSRRM conditions. Maximum arteriolar diameter (determined during superfusion with Ca2+-free solution containing 10−4M adenosine) was reduced in HS and HSRRM rats, suggesting anatomic remodeling of the vessels. In normotensive animals on the HS diet, the decreased reactivity was in proportion to the remodeling so the sensitivity index (vascular reactivity corrected for the anatomic remodeling) was not altered. Vascular responses in HSRRM rats were depressed to an extent disproportionate to the remodeling, so that the sensitivity index to the vasodilator agonists was significantly reduced. We conclude that HSRRM hypertension and HS diet (independent of hypertension) can have significant effects on the structure of microvessels and on the reactivity of the arterioles to dilator agonists. The severity of these alterations is greater in HSRRM hypertension than in normotensive rats on HS diets." @default.
- W2003011648 created "2016-06-24" @default.
- W2003011648 creator A5000886546 @default.
- W2003011648 creator A5075058971 @default.
- W2003011648 date "1998-11-01" @default.
- W2003011648 modified "2023-10-15" @default.
- W2003011648 title "Chronic Elevations in Salt Intake and Reduced Renal Mass Hypertension Compromise Mechanisms of Arteriolar Dilation" @default.
- W2003011648 cites W1989682644 @default.
- W2003011648 cites W2008112638 @default.
- W2003011648 cites W2023270541 @default.
- W2003011648 cites W2035781216 @default.
- W2003011648 cites W2076748620 @default.
- W2003011648 cites W2118463160 @default.
- W2003011648 doi "https://doi.org/10.1006/mvre.1998.2105" @default.
- W2003011648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9828160" @default.
- W2003011648 hasPublicationYear "1998" @default.
- W2003011648 type Work @default.
- W2003011648 sameAs 2003011648 @default.
- W2003011648 citedByCount "53" @default.
- W2003011648 countsByYear W20030116482013 @default.
- W2003011648 countsByYear W20030116482014 @default.
- W2003011648 countsByYear W20030116482015 @default.
- W2003011648 countsByYear W20030116482016 @default.
- W2003011648 countsByYear W20030116482018 @default.
- W2003011648 crossrefType "journal-article" @default.
- W2003011648 hasAuthorship W2003011648A5000886546 @default.
- W2003011648 hasAuthorship W2003011648A5075058971 @default.
- W2003011648 hasConcept C120770815 @default.
- W2003011648 hasConcept C126322002 @default.
- W2003011648 hasConcept C12722491 @default.
- W2003011648 hasConcept C134018914 @default.
- W2003011648 hasConcept C185592680 @default.
- W2003011648 hasConcept C2776354463 @default.
- W2003011648 hasConcept C2777032099 @default.
- W2003011648 hasConcept C2779482390 @default.
- W2003011648 hasConcept C2779610285 @default.
- W2003011648 hasConcept C2779959927 @default.
- W2003011648 hasConcept C2781103887 @default.
- W2003011648 hasConcept C2781128415 @default.
- W2003011648 hasConcept C519581460 @default.
- W2003011648 hasConcept C71924100 @default.
- W2003011648 hasConceptScore W2003011648C120770815 @default.
- W2003011648 hasConceptScore W2003011648C126322002 @default.
- W2003011648 hasConceptScore W2003011648C12722491 @default.
- W2003011648 hasConceptScore W2003011648C134018914 @default.
- W2003011648 hasConceptScore W2003011648C185592680 @default.
- W2003011648 hasConceptScore W2003011648C2776354463 @default.
- W2003011648 hasConceptScore W2003011648C2777032099 @default.
- W2003011648 hasConceptScore W2003011648C2779482390 @default.
- W2003011648 hasConceptScore W2003011648C2779610285 @default.
- W2003011648 hasConceptScore W2003011648C2779959927 @default.
- W2003011648 hasConceptScore W2003011648C2781103887 @default.
- W2003011648 hasConceptScore W2003011648C2781128415 @default.
- W2003011648 hasConceptScore W2003011648C519581460 @default.
- W2003011648 hasConceptScore W2003011648C71924100 @default.
- W2003011648 hasIssue "3" @default.
- W2003011648 hasLocation W20030116481 @default.
- W2003011648 hasLocation W20030116482 @default.
- W2003011648 hasOpenAccess W2003011648 @default.
- W2003011648 hasPrimaryLocation W20030116481 @default.
- W2003011648 hasRelatedWork W1964099886 @default.
- W2003011648 hasRelatedWork W1975762558 @default.
- W2003011648 hasRelatedWork W1985445708 @default.
- W2003011648 hasRelatedWork W2014670519 @default.
- W2003011648 hasRelatedWork W2018016719 @default.
- W2003011648 hasRelatedWork W2080968453 @default.
- W2003011648 hasRelatedWork W2353804531 @default.
- W2003011648 hasRelatedWork W2394843443 @default.
- W2003011648 hasRelatedWork W2412454599 @default.
- W2003011648 hasRelatedWork W1967428376 @default.
- W2003011648 hasVolume "56" @default.
- W2003011648 isParatext "false" @default.
- W2003011648 isRetracted "false" @default.
- W2003011648 magId "2003011648" @default.
- W2003011648 workType "article" @default.