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• W2003013429 abstract "Recent studies in our laboratories have demonstrated that a helical polypeptide (17H6), equipped with a histidine tag and a helical alanine-rich, glutamic-acid-containing domain, exhibits pH-responsive assembly behavior useful in the production of polymorphological nanostructures. In this study, the histidine tag in these polypeptides was replaced by polyethylene glycol (PEG) with different molecular masses (5 kDa, or 10 kDa), and the self-association behavior of 17H6 and the PEGylated conjugates was characterized via dynamic light scattering (DLS), small angle neutron scattering (SANS), and cryogenic transmission electron microscopy (cryo-TEM). DLS experiments illustrated that the polypeptide and its PEG-conjugates undergo reversible assembly under acidic conditions, suggesting that the aggregation state of the polypeptide and the conjugates is controlled by the charged state of the glutamic acid residues. Nanoscale aggregates were detected at polypeptide/conjugate concentrations as low as 20 μM (∼0.3-0.5 mg ml-1) at physiological and ambient temperatures. Scattering and microscopy results showed that the size, the aggregation number, and the morphology of the aggregates can be tuned by the size and the nature of the hydrophilic tag. This tunable nature of the morphology of the aggregates, along with their low critical aggregation concentration, suggests that PEG-alanine-rich polypeptide conjugates may be useful as drug delivery vehicles in which the alanine-rich block serves as a drug attachment domain." @default.
• W2003013429 created "2016-06-24" @default.
• W2003013429 creator A5046514790 @default.
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• W2003013429 creator A5059462769 @default.
• W2003013429 creator A5062296756 @default.
• W2003013429 creator A5081116859 @default.
• W2003013429 date "2011-10-20" @default.
• W2003013429 modified "2023-10-18" @default.
• W2003013429 title "Controlling assembly of helical polypeptides via PEGylation strategies." @default.
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• W2003013429 doi "https://doi.org/10.1039/c1sm05686g" @default.
• W2003013429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3769986" @default.
• W2003013429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24039625" @default.
• W2003013429 hasPublicationYear "2011" @default.
• W2003013429 type Work @default.
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