Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003013703> ?p ?o ?g. }
- W2003013703 endingPage "625" @default.
- W2003013703 startingPage "614" @default.
- W2003013703 abstract "Nonsteroidal anti-inflammat ory drugs (NSAIDs) are one of the drug types frequently prescribed for their analgesic, anti-inflammatory, and antithrombotic actions, but carry a risk of major gastroduodenal damage from mild erosive changes to serious ulceration leading to fatal outcomes. From the long history of willow tree bark and its extracts being applied for the relief of pain and fever, the synthesis of acetylsalicylic acid, the development of selective cyclooxygenase 2 inhibitors (coxibs), and the identification of a G-protein-coupled receptor for prostaglandin, the popular combination regimen of an NSAID and a proton pump inhibitor was invented, but development was continued for further improvement. With regard to major NSAID adverse effects, gastrointestinal (GI) and cardiovascular (CV) risks still remained as problems to be solved. In this review, it is shown that n-3 polyunsaturated fatty acid (PUFA) based NSAIDs can be an angelus custos, supported with facts that an intake of essential n-3 PUFAs orchestrates concerted protective actions against two notorious side effects of NSAIDs, the aforementioned GI risk and CV risk of NSAIDs. Since pills containing n-3 PUFAs, omega-3-acid ethyl ester capsules (Lovaza, Omarcor), have already been safely prescribed to prevent atherosclerosis through lessening lipid burdening, the introduction of a drug delivery system such as a gastroretentive form of n-3 PUFA based NSAIDs will highlight newer hope for GI safety under the guarantee of reduced CV risk. Because n-3 PUFAs have been proven to attenuate cytotoxicity, inhibit lipid-raft-associated harmful signaling, and relieve oxidative stress relevant to NSAIDs, n-3 PUFA based NSAIDs will be next-generation GI-safe NSAIDs." @default.
- W2003013703 created "2016-06-24" @default.
- W2003013703 creator A5019341254 @default.
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- W2003013703 creator A5059751861 @default.
- W2003013703 creator A5068922436 @default.
- W2003013703 creator A5076725471 @default.
- W2003013703 creator A5089791216 @default.
- W2003013703 date "2015-01-13" @default.
- W2003013703 modified "2023-10-04" @default.
- W2003013703 title "Omega-3 polyunsaturated fatty acids as an angelus custos to rescue patients from NSAID-induced gastroduodenal damage" @default.
- W2003013703 cites W11112109 @default.
- W2003013703 cites W1523693806 @default.
- W2003013703 cites W1533021978 @default.
- W2003013703 cites W1578779604 @default.
- W2003013703 cites W163232253 @default.
- W2003013703 cites W1696994176 @default.
- W2003013703 cites W1926261341 @default.
- W2003013703 cites W1956700960 @default.
- W2003013703 cites W1965192208 @default.
- W2003013703 cites W1966227086 @default.
- W2003013703 cites W1969901783 @default.
- W2003013703 cites W1974121989 @default.
- W2003013703 cites W1977523943 @default.
- W2003013703 cites W1978212781 @default.
- W2003013703 cites W1981044636 @default.
- W2003013703 cites W1981406908 @default.
- W2003013703 cites W1984368960 @default.
- W2003013703 cites W1986412959 @default.
- W2003013703 cites W1999224453 @default.
- W2003013703 cites W2000131951 @default.
- W2003013703 cites W2000346583 @default.
- W2003013703 cites W2000959972 @default.
- W2003013703 cites W2002350293 @default.
- W2003013703 cites W2002924275 @default.
- W2003013703 cites W2003880412 @default.
- W2003013703 cites W2004313693 @default.
- W2003013703 cites W2009513609 @default.
- W2003013703 cites W2013333442 @default.
- W2003013703 cites W2015336843 @default.
- W2003013703 cites W2016407358 @default.
- W2003013703 cites W2018490767 @default.
- W2003013703 cites W2021081864 @default.
- W2003013703 cites W2021882008 @default.
- W2003013703 cites W2026658367 @default.
- W2003013703 cites W2028986871 @default.
- W2003013703 cites W2029734068 @default.
- W2003013703 cites W2030354761 @default.
- W2003013703 cites W2034888385 @default.
- W2003013703 cites W2041565060 @default.
- W2003013703 cites W2047848796 @default.
- W2003013703 cites W2048030072 @default.
- W2003013703 cites W2048167823 @default.
- W2003013703 cites W2049435483 @default.
- W2003013703 cites W2053282906 @default.
- W2003013703 cites W2054244888 @default.
- W2003013703 cites W2055191327 @default.
- W2003013703 cites W2055312417 @default.
- W2003013703 cites W2063397701 @default.
- W2003013703 cites W2063497441 @default.
- W2003013703 cites W2063811212 @default.
- W2003013703 cites W2065278629 @default.
- W2003013703 cites W2065359879 @default.
- W2003013703 cites W2068984440 @default.
- W2003013703 cites W2069551187 @default.
- W2003013703 cites W2070047919 @default.
- W2003013703 cites W2077991556 @default.
- W2003013703 cites W2079927743 @default.
- W2003013703 cites W2081839805 @default.
- W2003013703 cites W2082921087 @default.
- W2003013703 cites W2083464592 @default.
- W2003013703 cites W2084260196 @default.
- W2003013703 cites W2085496617 @default.
- W2003013703 cites W2086520150 @default.
- W2003013703 cites W2094051823 @default.
- W2003013703 cites W2095146642 @default.
- W2003013703 cites W2095454778 @default.
- W2003013703 cites W2096281612 @default.
- W2003013703 cites W2096916760 @default.
- W2003013703 cites W2097111776 @default.
- W2003013703 cites W2098628540 @default.
- W2003013703 cites W2098705946 @default.
- W2003013703 cites W2100419904 @default.
- W2003013703 cites W2103136574 @default.
- W2003013703 cites W2103161616 @default.
- W2003013703 cites W2103413039 @default.
- W2003013703 cites W2108687569 @default.
- W2003013703 cites W2109034822 @default.
- W2003013703 cites W2110902451 @default.
- W2003013703 cites W2111253176 @default.
- W2003013703 cites W2111989705 @default.
- W2003013703 cites W2118120457 @default.
- W2003013703 cites W2118559794 @default.
- W2003013703 cites W2125555008 @default.
- W2003013703 cites W2130359297 @default.
- W2003013703 cites W2132790109 @default.
- W2003013703 cites W2135515147 @default.