FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003013800> ?p ?o ?g. }

• W2003013800 endingPage "320" @default.
• W2003013800 startingPage "313" @default.
• W2003013800 abstract "Ductal carcinoma in situ (DCIS) recurs in the same breast following breast-conserving surgery in 5%-25% of patients, with the rate influenced by the presence or absence of involved surgical margins, tumor size and nuclear grade, and whether or not radiation therapy was performed. A recurrent lesion arising soon after excision of an initial DCIS may reflect residual disease, whereas in situ tumors arising after longer periods are sometimes considered to be second independent events. The purpose of this study was to determine the clonal relationship between initial DCIS lesions and their recurrences.Comparative genomic hybridization (CGH) was used to compare chromosomal alterations in 18 initial DCIS lesions (presenting in the absence of invasive disease) and in their subsequent ipsilateral DCIS recurrences (detected from 16 months to 9.3 years later).Of the 18 tumor pairs, 17 showed a high concordance in their chromosomal alterations (median = 81%; range = 65%-100%), while one case showed no agreement between the paired samples (having two and 20 alterations, respectively). Morphologic characterization of the DCIS pairs showed clear similarities. The mean number of CGH changes was greater in the recurrent tumors than in the initial lesions (10.7 versus 8.8; P =.019). The most common changes in both the initial and the recurrent in situ lesions were gains involving chromosome 17q and losses involving chromosomes 8p and 17p. The degree of concordance was independent of the time interval before recurrence and of the presence of positive surgical margins.In this study, DCIS recurrences were clonally related to their primary lesions in most cases. This finding is consistent with treatment paradigms requiring wide surgical margins and/or postoperative radiation therapy." @default.
• W2003013800 created "2016-06-24" @default.
• W2003013800 creator A5011359891 @default.
• W2003013800 creator A5023200990 @default.
• W2003013800 creator A5027187873 @default.
• W2003013800 creator A5038915486 @default.
• W2003013800 creator A5059617881 @default.
• W2003013800 creator A5085257013 @default.
• W2003013800 date "2000-02-16" @default.
• W2003013800 modified "2023-10-18" @default.
• W2003013800 title "Chromosomal Alterations in Ductal Carcinomas In Situ and Their In Situ Recurrences" @default.
• W2003013800 cites W1488448478 @default.
• W2003013800 cites W1598808289 @default.
• W2003013800 cites W1615476194 @default.
• W2003013800 cites W177416928 @default.
• W2003013800 cites W1967497779 @default.
• W2003013800 cites W1967679930 @default.
• W2003013800 cites W1968046362 @default.
• W2003013800 cites W1999947134 @default.
• W2003013800 cites W2000656440 @default.
• W2003013800 cites W2002786604 @default.
• W2003013800 cites W2002978719 @default.
• W2003013800 cites W2009584097 @default.
• W2003013800 cites W2019972414 @default.
• W2003013800 cites W2023209386 @default.
• W2003013800 cites W2027418755 @default.
• W2003013800 cites W2030625872 @default.
• W2003013800 cites W2034147960 @default.
• W2003013800 cites W2062926746 @default.
• W2003013800 cites W2078491995 @default.
• W2003013800 cites W2085667759 @default.
• W2003013800 cites W2092508315 @default.
• W2003013800 cites W2097195427 @default.
• W2003013800 cites W2098034673 @default.
• W2003013800 cites W2100413302 @default.
• W2003013800 cites W2115740039 @default.
• W2003013800 cites W2115743878 @default.
• W2003013800 cites W2125185935 @default.
• W2003013800 cites W2156528167 @default.
• W2003013800 cites W2156604317 @default.
• W2003013800 cites W2156643308 @default.
• W2003013800 cites W2159670810 @default.
• W2003013800 cites W2318327263 @default.
• W2003013800 cites W2328238036 @default.
• W2003013800 cites W2407837086 @default.
• W2003013800 cites W2461941737 @default.
• W2003013800 cites W3025091880 @default.
• W2003013800 cites W56652881 @default.
• W2003013800 cites W591375881 @default.
• W2003013800 cites W98521928 @default.
• W2003013800 doi "https://doi.org/10.1093/jnci/92.4.313" @default.
• W2003013800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10675380" @default.
• W2003013800 hasPublicationYear "2000" @default.
• W2003013800 type Work @default.
• W2003013800 sameAs 2003013800 @default.
• W2003013800 citedByCount "155" @default.
• W2003013800 countsByYear W20030138002012 @default.
• W2003013800 countsByYear W20030138002013 @default.
• W2003013800 countsByYear W20030138002015 @default.
• W2003013800 countsByYear W20030138002016 @default.
• W2003013800 countsByYear W20030138002017 @default.
• W2003013800 countsByYear W20030138002018 @default.
• W2003013800 countsByYear W20030138002019 @default.
• W2003013800 countsByYear W20030138002020 @default.
• W2003013800 countsByYear W20030138002021 @default.
• W2003013800 countsByYear W20030138002022 @default.
• W2003013800 countsByYear W20030138002023 @default.
• W2003013800 crossrefType "journal-article" @default.
• W2003013800 hasAuthorship W2003013800A5011359891 @default.
• W2003013800 hasAuthorship W2003013800A5023200990 @default.
• W2003013800 hasAuthorship W2003013800A5027187873 @default.
• W2003013800 hasAuthorship W2003013800A5038915486 @default.
• W2003013800 hasAuthorship W2003013800A5059617881 @default.
• W2003013800 hasAuthorship W2003013800A5085257013 @default.
• W2003013800 hasBestOaLocation W20030138002 @default.
• W2003013800 hasConcept C104317684 @default.
• W2003013800 hasConcept C121332964 @default.
• W2003013800 hasConcept C121608353 @default.
• W2003013800 hasConcept C124942203 @default.
• W2003013800 hasConcept C126322002 @default.
• W2003013800 hasConcept C142724271 @default.
• W2003013800 hasConcept C153294291 @default.
• W2003013800 hasConcept C160798450 @default.
• W2003013800 hasConcept C2777546739 @default.
• W2003013800 hasConcept C2777661416 @default.
• W2003013800 hasConcept C2777822432 @default.
• W2003013800 hasConcept C2778001805 @default.
• W2003013800 hasConcept C2780862961 @default.
• W2003013800 hasConcept C30481170 @default.
• W2003013800 hasConcept C530470458 @default.
• W2003013800 hasConcept C54355233 @default.
• W2003013800 hasConcept C71924100 @default.
• W2003013800 hasConcept C86803240 @default.
• W2003013800 hasConceptScore W2003013800C104317684 @default.
• W2003013800 hasConceptScore W2003013800C121332964 @default.
• W2003013800 hasConceptScore W2003013800C121608353 @default.
• W2003013800 hasConceptScore W2003013800C124942203 @default.
• W2003013800 hasConceptScore W2003013800C126322002 @default.

• next