Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003013939> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2003013939 endingPage "436" @default.
- W2003013939 startingPage "428" @default.
- W2003013939 abstract "Chronic atrial fibrillation (AF) is characterized by decreased atrial contractility, shortened action potential duration, and decreased accommodation of action potential duration to changes in activation rate. Studies on experimental animal models of AF implicate a reduction in L-type Ca2+ current (I(Ca)) density in these changes. To evaluate the effect of AF on human I(Ca), we compared I(Ca) in atrial myocytes isolated from 42 patients in normal sinus rhythm at the time of cardiac surgery with that of 11 chronic AF patients. I(Ca) was significantly reduced in the myocytes of patients with chronic AF (mean -3.35+/-0.5 pA/pF versus -9.13+/-1. 0 pA/pF in the controls), with no difference between groups in the voltage dependence of activation or steady-state inactivation. Although I(Ca) was lower in myocytes from the chronic AF patients, their response to maximal beta-adrenergic stimulation was not impaired. Postoperative AF frequently follows cardiac surgery. Half of the patients in the control group (19/38) of this study experienced postoperative AF. Whereas chronic AF is characterized by reduced atrial I(Ca), the patients with the greatest I(Ca) had an increased incidence of postoperative AF, independent of patient age or diagnosis. This observation is consistent with the concept that calcium overload may be an important factor in the initiation of AF. The reduction in functional I(Ca) density in myocytes from the atria of chronic AF patients may thus be an adaptive response to the arrhythmia-induced calcium overload." @default.
- W2003013939 created "2016-06-24" @default.
- W2003013939 creator A5000457940 @default.
- W2003013939 creator A5025308337 @default.
- W2003013939 creator A5029095556 @default.
- W2003013939 creator A5061706688 @default.
- W2003013939 creator A5079314197 @default.
- W2003013939 creator A5087985631 @default.
- W2003013939 date "1999-09-03" @default.
- W2003013939 modified "2023-10-12" @default.
- W2003013939 title "Atrial L-Type Ca <sup>2+</sup> Currents and Human Atrial Fibrillation" @default.
- W2003013939 cites W1508529139 @default.
- W2003013939 cites W1561086309 @default.
- W2003013939 cites W1976772037 @default.
- W2003013939 cites W1989282030 @default.
- W2003013939 cites W1994441999 @default.
- W2003013939 cites W1998874168 @default.
- W2003013939 cites W2015937728 @default.
- W2003013939 cites W2029606950 @default.
- W2003013939 cites W2040649250 @default.
- W2003013939 cites W2061804238 @default.
- W2003013939 cites W2066507239 @default.
- W2003013939 cites W2081384297 @default.
- W2003013939 cites W2094470005 @default.
- W2003013939 cites W2098924056 @default.
- W2003013939 cites W2104749146 @default.
- W2003013939 cites W2396389869 @default.
- W2003013939 doi "https://doi.org/10.1161/01.res.85.5.428" @default.
- W2003013939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10473672" @default.
- W2003013939 hasPublicationYear "1999" @default.
- W2003013939 type Work @default.
- W2003013939 sameAs 2003013939 @default.
- W2003013939 citedByCount "475" @default.
- W2003013939 countsByYear W20030139392012 @default.
- W2003013939 countsByYear W20030139392013 @default.
- W2003013939 countsByYear W20030139392014 @default.
- W2003013939 countsByYear W20030139392015 @default.
- W2003013939 countsByYear W20030139392016 @default.
- W2003013939 countsByYear W20030139392017 @default.
- W2003013939 countsByYear W20030139392018 @default.
- W2003013939 countsByYear W20030139392019 @default.
- W2003013939 countsByYear W20030139392020 @default.
- W2003013939 countsByYear W20030139392021 @default.
- W2003013939 countsByYear W20030139392022 @default.
- W2003013939 countsByYear W20030139392023 @default.
- W2003013939 crossrefType "journal-article" @default.
- W2003013939 hasAuthorship W2003013939A5000457940 @default.
- W2003013939 hasAuthorship W2003013939A5025308337 @default.
- W2003013939 hasAuthorship W2003013939A5029095556 @default.
- W2003013939 hasAuthorship W2003013939A5061706688 @default.
- W2003013939 hasAuthorship W2003013939A5079314197 @default.
- W2003013939 hasAuthorship W2003013939A5087985631 @default.
- W2003013939 hasBestOaLocation W20030139391 @default.
- W2003013939 hasConcept C114021368 @default.
- W2003013939 hasConcept C126322002 @default.
- W2003013939 hasConcept C134018914 @default.
- W2003013939 hasConcept C164705383 @default.
- W2003013939 hasConcept C207200792 @default.
- W2003013939 hasConcept C2775914520 @default.
- W2003013939 hasConcept C2778198053 @default.
- W2003013939 hasConcept C2779161974 @default.
- W2003013939 hasConcept C3018640507 @default.
- W2003013939 hasConcept C39133596 @default.
- W2003013939 hasConcept C519063684 @default.
- W2003013939 hasConcept C71924100 @default.
- W2003013939 hasConceptScore W2003013939C114021368 @default.
- W2003013939 hasConceptScore W2003013939C126322002 @default.
- W2003013939 hasConceptScore W2003013939C134018914 @default.
- W2003013939 hasConceptScore W2003013939C164705383 @default.
- W2003013939 hasConceptScore W2003013939C207200792 @default.
- W2003013939 hasConceptScore W2003013939C2775914520 @default.
- W2003013939 hasConceptScore W2003013939C2778198053 @default.
- W2003013939 hasConceptScore W2003013939C2779161974 @default.
- W2003013939 hasConceptScore W2003013939C3018640507 @default.
- W2003013939 hasConceptScore W2003013939C39133596 @default.
- W2003013939 hasConceptScore W2003013939C519063684 @default.
- W2003013939 hasConceptScore W2003013939C71924100 @default.
- W2003013939 hasIssue "5" @default.
- W2003013939 hasLocation W20030139391 @default.
- W2003013939 hasLocation W20030139392 @default.
- W2003013939 hasOpenAccess W2003013939 @default.
- W2003013939 hasPrimaryLocation W20030139391 @default.
- W2003013939 hasRelatedWork W180318050 @default.
- W2003013939 hasRelatedWork W1991051841 @default.
- W2003013939 hasRelatedWork W2067521072 @default.
- W2003013939 hasRelatedWork W2081830074 @default.
- W2003013939 hasRelatedWork W2100349116 @default.
- W2003013939 hasRelatedWork W2368598009 @default.
- W2003013939 hasRelatedWork W2375499427 @default.
- W2003013939 hasRelatedWork W2441966140 @default.
- W2003013939 hasRelatedWork W3035717490 @default.
- W2003013939 hasRelatedWork W4299464480 @default.
- W2003013939 hasVolume "85" @default.
- W2003013939 isParatext "false" @default.
- W2003013939 isRetracted "false" @default.
- W2003013939 magId "2003013939" @default.
- W2003013939 workType "article" @default.