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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003014566> ?p ?o ?g. }

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• W2003014566 abstract "Secretory vesicles purified from the neural and intermediate lobes of the bovine pituitary contain acidic endopeptidases which are capable of converting renin tetradecapeptide (RTD) substrate to Angiotensin I (AI). Preliminary characterization of the neurosecretory vesicle (NSV) endopeptidase showed that it had a pH optimum of 4.0, and unlike renin was inactive at pHs > 6.0. It is inhibited by 10−6M pepstatin A, but not by PMSF, leupeptin, PMBS, or the specific renin inhibitor H-142. This NSV endopeptidase differed from cathepsin D in that it was unable to degrade α-casein, but was quite active in generating AI from RTD (Vmax = 5 moles/g protein/hour). No enzyme activity that could convert AI to Angiotensin II could be detected in the NSVs suggesting that the acidic endopeptidase is involved in processing neurosecretory vesicle proteins other than those associated with the renin angiotensin system in the brain." @default.
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• W2003014566 date "1984-11-01" @default.
• W2003014566 modified "2023-09-24" @default.
• W2003014566 title "Angiotensin I-generating acid endopeptidase activity in neurosecretory vesicles isolated from bovine pituitary" @default.
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• W2003014566 doi "https://doi.org/10.1016/0143-4179(84)90088-x" @default.
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