Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003014738> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2003014738 endingPage "416" @default.
- W2003014738 startingPage "409" @default.
- W2003014738 abstract "Serum ferritin concentrations have been measured in 124 patients with homozygous β thalassaemia who were between 2 and 21 years old, had received 11–504 units of blood but had not undergone splenectorny. There were highly significant correlations between serum ferritin concentration and both the amount of blood transfused and alanine amino-transferase (ALT) activity. However, multivariate analysis showed that units of blood and ALT activity together only accounted for about 30% of the variation in serum ferritin concentration. Little of the remaining variation could be explained by other variables related to iron nietabolism or liver damage. The concentration of concanavalin A binding ferritin increased rapidly with the number of units of blood up to 100 units but thereafter showed no further increase with number of transfusions. The concentration of non-binding ferritin was more closely related to transfusion load. These results suggest that the secretion of glycosylated ferritin from rcticuloendothelial cells reaches a maximum with increasing iron accumulation, perhaps reflecting a maximum rate of synthesis. Ferritinaemia in patients with transfusional iron overload therefore seems to be the result of the combined effects of increased ferritin synthesis and the release of intracellular ferritin from damaged cells. A simple relationship between serum ferritin and iron stores cannot be assumed when ferritin concentrations exceed 4000 μg/l or in patients who have received more than 100 units of transfused blood." @default.
- W2003014738 created "2016-06-24" @default.
- W2003014738 creator A5006177671 @default.
- W2003014738 creator A5021454167 @default.
- W2003014738 creator A5028410044 @default.
- W2003014738 creator A5055925524 @default.
- W2003014738 creator A5058120847 @default.
- W2003014738 creator A5061749043 @default.
- W2003014738 date "1980-11-01" @default.
- W2003014738 modified "2023-09-23" @default.
- W2003014738 title "Binding of Serum Ferritin to Concanavalin A: Patients with Hornozygous β Thalassaemia and Transfusional Iron Overload" @default.
- W2003014738 cites W1542064370 @default.
- W2003014738 cites W160412982 @default.
- W2003014738 cites W1979963465 @default.
- W2003014738 cites W1989437953 @default.
- W2003014738 cites W2007036987 @default.
- W2003014738 cites W2025018651 @default.
- W2003014738 cites W2032678934 @default.
- W2003014738 cites W2074602083 @default.
- W2003014738 cites W2079759895 @default.
- W2003014738 cites W2083737171 @default.
- W2003014738 cites W2090618731 @default.
- W2003014738 cites W2120251024 @default.
- W2003014738 cites W2146696132 @default.
- W2003014738 cites W2312779688 @default.
- W2003014738 cites W2337665085 @default.
- W2003014738 cites W2340473515 @default.
- W2003014738 cites W243057007 @default.
- W2003014738 cites W4211073943 @default.
- W2003014738 doi "https://doi.org/10.1111/j.1365-2141.1980.tb05987.x" @default.
- W2003014738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7448126" @default.
- W2003014738 hasPublicationYear "1980" @default.
- W2003014738 type Work @default.
- W2003014738 sameAs 2003014738 @default.
- W2003014738 citedByCount "89" @default.
- W2003014738 countsByYear W20030147382013 @default.
- W2003014738 countsByYear W20030147382015 @default.
- W2003014738 countsByYear W20030147382016 @default.
- W2003014738 countsByYear W20030147382017 @default.
- W2003014738 countsByYear W20030147382018 @default.
- W2003014738 countsByYear W20030147382019 @default.
- W2003014738 countsByYear W20030147382022 @default.
- W2003014738 countsByYear W20030147382023 @default.
- W2003014738 crossrefType "journal-article" @default.
- W2003014738 hasAuthorship W2003014738A5006177671 @default.
- W2003014738 hasAuthorship W2003014738A5021454167 @default.
- W2003014738 hasAuthorship W2003014738A5028410044 @default.
- W2003014738 hasAuthorship W2003014738A5055925524 @default.
- W2003014738 hasAuthorship W2003014738A5058120847 @default.
- W2003014738 hasAuthorship W2003014738A5061749043 @default.
- W2003014738 hasConcept C126322002 @default.
- W2003014738 hasConcept C134018914 @default.
- W2003014738 hasConcept C185592680 @default.
- W2003014738 hasConcept C19869320 @default.
- W2003014738 hasConcept C202751555 @default.
- W2003014738 hasConcept C203014093 @default.
- W2003014738 hasConcept C2778319317 @default.
- W2003014738 hasConcept C3019184707 @default.
- W2003014738 hasConcept C55493867 @default.
- W2003014738 hasConcept C71924100 @default.
- W2003014738 hasConceptScore W2003014738C126322002 @default.
- W2003014738 hasConceptScore W2003014738C134018914 @default.
- W2003014738 hasConceptScore W2003014738C185592680 @default.
- W2003014738 hasConceptScore W2003014738C19869320 @default.
- W2003014738 hasConceptScore W2003014738C202751555 @default.
- W2003014738 hasConceptScore W2003014738C203014093 @default.
- W2003014738 hasConceptScore W2003014738C2778319317 @default.
- W2003014738 hasConceptScore W2003014738C3019184707 @default.
- W2003014738 hasConceptScore W2003014738C55493867 @default.
- W2003014738 hasConceptScore W2003014738C71924100 @default.
- W2003014738 hasIssue "3" @default.
- W2003014738 hasLocation W20030147381 @default.
- W2003014738 hasLocation W20030147382 @default.
- W2003014738 hasOpenAccess W2003014738 @default.
- W2003014738 hasPrimaryLocation W20030147381 @default.
- W2003014738 hasRelatedWork W1966504330 @default.
- W2003014738 hasRelatedWork W1979139803 @default.
- W2003014738 hasRelatedWork W2010102659 @default.
- W2003014738 hasRelatedWork W2037631372 @default.
- W2003014738 hasRelatedWork W2088795660 @default.
- W2003014738 hasRelatedWork W2114510857 @default.
- W2003014738 hasRelatedWork W2148095482 @default.
- W2003014738 hasRelatedWork W2398568073 @default.
- W2003014738 hasRelatedWork W2748952813 @default.
- W2003014738 hasRelatedWork W2899084033 @default.
- W2003014738 hasVolume "46" @default.
- W2003014738 isParatext "false" @default.
- W2003014738 isRetracted "false" @default.
- W2003014738 magId "2003014738" @default.
- W2003014738 workType "article" @default.