Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003015610> ?p ?o ?g. }
- W2003015610 endingPage "116" @default.
- W2003015610 startingPage "105" @default.
- W2003015610 abstract "Glial cell line-derived neurotrophic factor (GDNF) is a specific neurotrophic factor for midbrain dopamine (DA) neurons, but the mechanism underlying the neurotrophic action of GDNF is not well known. The cell adhesion molecules integrin and Neural cell adhesion molecule (NCAM) play important roles in neurite outgrowth and fasciculation. In the present study, we found that subchronic GDNF administration to the pars compacta of substantia nigra in rats increased the expression of integrin alphav and NCAM. Immunostaining results demonstrated the wide distribution of integrin alphav and NCAM in all mesencephalic neurons. The results also demonstrated the co-expression of TH with integrin alphav and NCAM in the same neurons of mesencephalic culture. Further, GDNF significantly increased integrin alphav expression in single TH-positive neurons. Function-blocking anti-integrin alphav and anti-NCAM antibodies antagonized the effects of GDNF on DA neuron survival, outgrowth, DA turnover, and locomotor activity in rats. These results demonstrate that integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival and outgrowth during development and on DA turnover and motor function during adulthood." @default.
- W2003015610 created "2016-06-24" @default.
- W2003015610 creator A5030245334 @default.
- W2003015610 date "2003-02-01" @default.
- W2003015610 modified "2023-10-18" @default.
- W2003015610 title "Integrin αv and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats" @default.
- W2003015610 cites W1516340190 @default.
- W2003015610 cites W1559916774 @default.
- W2003015610 cites W1584039439 @default.
- W2003015610 cites W1585757291 @default.
- W2003015610 cites W1668763770 @default.
- W2003015610 cites W1672471316 @default.
- W2003015610 cites W1850667805 @default.
- W2003015610 cites W1900535849 @default.
- W2003015610 cites W1928244427 @default.
- W2003015610 cites W1941658825 @default.
- W2003015610 cites W1972998445 @default.
- W2003015610 cites W1975369357 @default.
- W2003015610 cites W1976106371 @default.
- W2003015610 cites W1977780888 @default.
- W2003015610 cites W1988791308 @default.
- W2003015610 cites W1988919131 @default.
- W2003015610 cites W1989053030 @default.
- W2003015610 cites W1998225655 @default.
- W2003015610 cites W1999409442 @default.
- W2003015610 cites W2015323397 @default.
- W2003015610 cites W2023524874 @default.
- W2003015610 cites W2026411799 @default.
- W2003015610 cites W2029725727 @default.
- W2003015610 cites W2035381900 @default.
- W2003015610 cites W2037025785 @default.
- W2003015610 cites W2040384956 @default.
- W2003015610 cites W2041281774 @default.
- W2003015610 cites W2041613013 @default.
- W2003015610 cites W2043646028 @default.
- W2003015610 cites W2046378363 @default.
- W2003015610 cites W2046811970 @default.
- W2003015610 cites W2049267143 @default.
- W2003015610 cites W2054810445 @default.
- W2003015610 cites W2056184820 @default.
- W2003015610 cites W2060154208 @default.
- W2003015610 cites W2066367871 @default.
- W2003015610 cites W2070863782 @default.
- W2003015610 cites W2074150565 @default.
- W2003015610 cites W2078694877 @default.
- W2003015610 cites W2080306322 @default.
- W2003015610 cites W2092809361 @default.
- W2003015610 cites W2093127280 @default.
- W2003015610 cites W2100577875 @default.
- W2003015610 cites W2105716404 @default.
- W2003015610 cites W2106229630 @default.
- W2003015610 cites W2106291035 @default.
- W2003015610 cites W2107012136 @default.
- W2003015610 cites W2114008760 @default.
- W2003015610 cites W2121965026 @default.
- W2003015610 cites W2136081540 @default.
- W2003015610 cites W2138559670 @default.
- W2003015610 cites W2138894342 @default.
- W2003015610 cites W2139661803 @default.
- W2003015610 cites W2142479550 @default.
- W2003015610 cites W2156480888 @default.
- W2003015610 cites W2156679476 @default.
- W2003015610 cites W2158071716 @default.
- W2003015610 cites W2158335375 @default.
- W2003015610 cites W2160439002 @default.
- W2003015610 cites W2171960232 @default.
- W2003015610 cites W2170368391 @default.
- W2003015610 doi "https://doi.org/10.1016/s0197-4580(02)00047-7" @default.
- W2003015610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12493556" @default.
- W2003015610 hasPublicationYear "2003" @default.
- W2003015610 type Work @default.
- W2003015610 sameAs 2003015610 @default.
- W2003015610 citedByCount "75" @default.
- W2003015610 countsByYear W20030156102012 @default.
- W2003015610 countsByYear W20030156102013 @default.
- W2003015610 countsByYear W20030156102014 @default.
- W2003015610 countsByYear W20030156102015 @default.
- W2003015610 countsByYear W20030156102016 @default.
- W2003015610 countsByYear W20030156102017 @default.
- W2003015610 countsByYear W20030156102018 @default.
- W2003015610 countsByYear W20030156102019 @default.
- W2003015610 countsByYear W20030156102020 @default.
- W2003015610 countsByYear W20030156102021 @default.
- W2003015610 countsByYear W20030156102022 @default.
- W2003015610 countsByYear W20030156102023 @default.
- W2003015610 crossrefType "journal-article" @default.
- W2003015610 hasAuthorship W2003015610A5030245334 @default.
- W2003015610 hasConcept C113246987 @default.
- W2003015610 hasConcept C122871604 @default.
- W2003015610 hasConcept C137183658 @default.
- W2003015610 hasConcept C1491633281 @default.
- W2003015610 hasConcept C160539049 @default.
- W2003015610 hasConcept C169760540 @default.
- W2003015610 hasConcept C170493617 @default.
- W2003015610 hasConcept C185592680 @default.
- W2003015610 hasConcept C185856081 @default.
- W2003015610 hasConcept C195687474 @default.
- W2003015610 hasConcept C202751555 @default.