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- W2003017659 abstract "The effect of benserazide, an aromatic L-amino acid decarboxylase inhibitor, has been investigated on pineal 5-hydroxytryptamine content, melatonin synthesising enzyme activities and serum melatonin concn. Increasing doses of benserazide caused increasing reductions in the pineal content of 5-hydroxytryptamine. Dark phase serum melatonin concns were also greatly reduced. The drug abolished the diurnal rhythm of hydroxyindole-O-methyltransferase by increasing the light period activities and decreasing the night levels of this enzyme. Pineal N-acetyltransferase was unaffected. It is concluded that benserazide probably inhibits melatonin synthesis by preventing the formation of the substrate, 5-hydroxytryptamine." @default.
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- W2003017659 modified "2023-09-25" @default.
- W2003017659 title "Effect of benserazide on the levels of pineal 5-hydroxytryptamine, melatonin synthesising enzymes and serum melatonin" @default.
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- W2003017659 doi "https://doi.org/10.1016/0006-2952(82)90110-1" @default.
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