Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003018102> ?p ?o ?g. }
- W2003018102 endingPage "716" @default.
- W2003018102 startingPage "708" @default.
- W2003018102 abstract "Nicotine/nicotine agonists, which have been proposed as therapeutic agents for the treatment of Alzheimer's disease and other neurodegenerative disorders, produce a wide variety of effects on the nervous system. Some mechanisms involved remain poorly understood. In this work, immunohistochemical techniques were used to determine the effect of nicotine on nerve growth factor (NGF) in the frontoparietal (motor, somatosensory) brain cortex of the albino rat. Nicotine was chronically administered intraperitoneally using osmotic pumps (0.35 mg nicotine base/kg body weight/day for 14 days). An increase in the number and the immunoreaction intensity of NGF-like positive pyramidal and nonpyramidal neurons of these cortical areas was observed after treatment. Immunopositive astroglial cells were always seen in sections of treated animals but not in controls. The neuropil of control animals was, in general, devoid of reaction, but in treated animals, immunopositive prolongations were located randomly, some in close association with capillaries. At the electron microscopic level, these prolongations were demonstrated as belonging to neurons (dendrites and axons) and astroglial cells. Nicotinic activation of selected neurons and glial cells seems to trigger NGF/neurotrophic mechanisms, suggesting their use may be of benefit in prevention and treatment of neurodegenerative diseases." @default.
- W2003018102 created "2016-06-24" @default.
- W2003018102 creator A5010500493 @default.
- W2003018102 creator A5014585689 @default.
- W2003018102 creator A5061547368 @default.
- W2003018102 creator A5062327048 @default.
- W2003018102 creator A5070242872 @default.
- W2003018102 creator A5072284001 @default.
- W2003018102 creator A5082593981 @default.
- W2003018102 creator A5089450827 @default.
- W2003018102 date "2003-07-09" @default.
- W2003018102 modified "2023-10-18" @default.
- W2003018102 title "Chronic nicotine administration increases NGF-like immunoreactivity in frontoparietal cerebral cortex" @default.
- W2003018102 cites W1544301323 @default.
- W2003018102 cites W1638939027 @default.
- W2003018102 cites W1678311389 @default.
- W2003018102 cites W1939947624 @default.
- W2003018102 cites W1969278386 @default.
- W2003018102 cites W1973998682 @default.
- W2003018102 cites W1979896676 @default.
- W2003018102 cites W1989000709 @default.
- W2003018102 cites W1990697473 @default.
- W2003018102 cites W1992623778 @default.
- W2003018102 cites W1994067502 @default.
- W2003018102 cites W2001382455 @default.
- W2003018102 cites W2001779502 @default.
- W2003018102 cites W2001788282 @default.
- W2003018102 cites W2006304751 @default.
- W2003018102 cites W2010936735 @default.
- W2003018102 cites W2015146783 @default.
- W2003018102 cites W2015426057 @default.
- W2003018102 cites W2018885303 @default.
- W2003018102 cites W2021139758 @default.
- W2003018102 cites W2021280501 @default.
- W2003018102 cites W2021611920 @default.
- W2003018102 cites W2024552379 @default.
- W2003018102 cites W2026745182 @default.
- W2003018102 cites W2027036629 @default.
- W2003018102 cites W2030069255 @default.
- W2003018102 cites W2032098659 @default.
- W2003018102 cites W2032781654 @default.
- W2003018102 cites W2038320547 @default.
- W2003018102 cites W2039667851 @default.
- W2003018102 cites W2041086280 @default.
- W2003018102 cites W2041264288 @default.
- W2003018102 cites W2041267132 @default.
- W2003018102 cites W2041637209 @default.
- W2003018102 cites W2042529247 @default.
- W2003018102 cites W2043650944 @default.
- W2003018102 cites W2045288252 @default.
- W2003018102 cites W2045309216 @default.
- W2003018102 cites W2047586903 @default.
- W2003018102 cites W2050495289 @default.
- W2003018102 cites W2050665562 @default.
- W2003018102 cites W2051779589 @default.
- W2003018102 cites W2052330846 @default.
- W2003018102 cites W2054628630 @default.
- W2003018102 cites W2054817926 @default.
- W2003018102 cites W2059977420 @default.
- W2003018102 cites W2062841992 @default.
- W2003018102 cites W2067031806 @default.
- W2003018102 cites W2068322456 @default.
- W2003018102 cites W2070121411 @default.
- W2003018102 cites W2072368655 @default.
- W2003018102 cites W2082808226 @default.
- W2003018102 cites W2099452732 @default.
- W2003018102 cites W2105233285 @default.
- W2003018102 cites W2109366922 @default.
- W2003018102 cites W2132590272 @default.
- W2003018102 cites W2132964818 @default.
- W2003018102 cites W2133966135 @default.
- W2003018102 cites W2139973055 @default.
- W2003018102 cites W2144573332 @default.
- W2003018102 cites W2157815289 @default.
- W2003018102 cites W2160490682 @default.
- W2003018102 cites W2160559062 @default.
- W2003018102 cites W2333964989 @default.
- W2003018102 cites W4293247451 @default.
- W2003018102 cites W4317639052 @default.
- W2003018102 doi "https://doi.org/10.1002/jnr.10688" @default.
- W2003018102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12929138" @default.
- W2003018102 hasPublicationYear "2003" @default.
- W2003018102 type Work @default.
- W2003018102 sameAs 2003018102 @default.
- W2003018102 citedByCount "22" @default.
- W2003018102 countsByYear W20030181022012 @default.
- W2003018102 countsByYear W20030181022013 @default.
- W2003018102 countsByYear W20030181022015 @default.
- W2003018102 countsByYear W20030181022017 @default.
- W2003018102 countsByYear W20030181022019 @default.
- W2003018102 countsByYear W20030181022020 @default.
- W2003018102 crossrefType "journal-article" @default.
- W2003018102 hasAuthorship W2003018102A5010500493 @default.
- W2003018102 hasAuthorship W2003018102A5014585689 @default.
- W2003018102 hasAuthorship W2003018102A5061547368 @default.
- W2003018102 hasAuthorship W2003018102A5062327048 @default.
- W2003018102 hasAuthorship W2003018102A5070242872 @default.
- W2003018102 hasAuthorship W2003018102A5072284001 @default.