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- W2003018744 abstract "In a prospective double-blind trial twelve malnourished patients with lung cancer were randomised to receive either placebo or hydrazine sulphate (60 mg three times daily) for 30 days. Fasting lysine flux was determined by a primed 4-hour continuous infusion of 14C-lysine before and after one month of hydrazine treatment. Baseline plasma lysine flux was 2580 (SD 580) μmol/h for the placebo group and 2510 (440) μmol/h for the hydrazine group. After one month the placebo group showed a slight rise to 2920 (450) μmol/h (p = 0·08) and the hydrazine group showed a significant fall to 1840 (750) μmol/h (p <0·05); serum albumin fell in the placebo group and was unchanged in the hydrazine group. Administration of hydrazine sulphate to reduce aminoacid flux may favourably influence the metabolic abnormalities in cancer cachexia." @default.
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- W2003018744 title "EFFECT OF HYDRAZINE SULPHATE ON WHOLE-BODY PROTEIN BREAKDOWN MEASURED BY 14C-LYSINE METABOLISM IN LUNG CANCER PATIENTS" @default.
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- W2003018744 doi "https://doi.org/10.1016/s0140-6736(87)90828-2" @default.
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