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• W2003019074 abstract "Abstract The occurrence of a nuclear cataract in the eye lens due to disruption of the α3C×46 connexin gene, Gja3 , is dependent on strain background in a mouse model, implicating factors that modify the pathology. The differences upon cataractogenesis in the urea soluble proteins of the lens of two mouse strains, C57BL/6J and 129/SvJ, were analyzed by a comparative proteomics approach. Determination of the complete proteome of an organ offers the opportunity to characterize at a molecular level, differences in gene expression and PTMs occurring during pathology and between individuals. The abundance of 63 protein species was altered between the strains. A unique aspect of this study is the identification of chaperonin subunit 6A, mortalin, ERp29, and syntaxin‐binding protein 6 in the eye lens. DNA polymorphisms resulting in nonconservative amino acid changes that led to altered physicochemical properties of the proteins were detected for mortalin, chaperonin subunit 6A, annexin A1, and possibly γ‐N crystallin. The results show HSP27/25 and/or ERp29 are the likely major modifying factors for cataractogenesis. Extension of the results suggests that small heat‐shock proteins have a major role for influencing cataract formation in humans." @default.
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• W2003019074 date "2008-12-01" @default.
• W2003019074 modified "2023-09-27" @default.
• W2003019074 title "Identification of proteins that modify cataract of mouse eye lens" @default.
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• W2003019074 doi "https://doi.org/10.1002/pmic.200800380" @default.
• W2003019074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3018240" @default.
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