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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003020809> ?p ?o ?g. }

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• W2003020809 abstract "Propranolol and the sodium-channel–blocking antiarrhythmic agent propafenone share structural features. Although propafenone's beta-blocking actions are readily demonstrable in vitro, clinically significant beta-blockade occurs inconsistently in vivo. In this study, we tested the hypothesis that genetically determined variations in the biotransformation of propafenone to its 5-hydroxy metabolite account for variations in the drug's beta-blocking action." @default.
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• W2003020809 date "1990-06-21" @default.
• W2003020809 modified "2023-10-16" @default.
• W2003020809 title "The Role of Genetically Determined Polymorphic Drug Metabolism in the Beta-Blockade Produced by Propafenone" @default.
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• W2003020809 doi "https://doi.org/10.1056/nejm199006213222502" @default.
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