FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003023906> ?p ?o ?g. }

• W2003023906 endingPage "8419" @default.
• W2003023906 startingPage "8415" @default.
• W2003023906 abstract "To obtain a homogeneous population of gamma delta T cells to investigate their role in an immune response, we have made a scid mouse doubly transgenic for rearranged gamma and delta genes. The receptor (KN6) encoded by these genes is specific for the major histocompatibility complex class I protein encoded by the T22b gene. This mouse contains high levels of transgenic gamma delta T cells in the spleen and thymus and no other T lymphocytes. Immunization of these KN6-scid (H-2d, TLd) mice with 10(7) C57BL/6J (abbreviated B6) (H-2b, TLb) spleen cells resulted in proliferation and activation of the gamma delta T cells in spleen and clearing of the allogeneic B6 lymphocytes. Subsequently, the majority of activated cells died by apoptosis and the remaining cells were anergic with regard to proliferation. The anergic cells did not respond to restimulation by B6 spleen cells in vitro or in vivo, and addition of exogenous interleukin 2 failed to restore the response to B6 cells. Cytotoxicity, a property of KN6+ cells during a primary stimulation, was no longer detectable in the proliferatively anergic cells. However, B6 spleen cells injected into mice primed 12 days previously were cleared with a much greater efficiency than on primary challenge and in an antigen-specific manner. We conclude that after exposure to antigen, gamma delta T cells rapidly proliferate into blasts; the majority of the blasts rapidly die, with the nonproliferating cells remaining in a highly active state for several weeks and able to initiate elimination of lymphoid cells bearing the TLb epitope." @default.
• W2003023906 created "2016-06-24" @default.
• W2003023906 creator A5014584657 @default.
• W2003023906 creator A5038557565 @default.
• W2003023906 creator A5043958921 @default.
• W2003023906 creator A5057574490 @default.
• W2003023906 creator A5058729669 @default.
• W2003023906 creator A5071933041 @default.
• W2003023906 creator A5072980336 @default.
• W2003023906 creator A5091653815 @default.
• W2003023906 date "1993-09-15" @default.
• W2003023906 modified "2023-10-18" @default.
• W2003023906 title "Gamma delta T cells differentiate into a functional but nonproliferative state during a normal immune response." @default.
• W2003023906 cites W1492322782 @default.
• W2003023906 cites W1494676471 @default.
• W2003023906 cites W1506066152 @default.
• W2003023906 cites W1516581843 @default.
• W2003023906 cites W1966388921 @default.
• W2003023906 cites W1972354503 @default.
• W2003023906 cites W1976261525 @default.
• W2003023906 cites W1979518727 @default.
• W2003023906 cites W1984473036 @default.
• W2003023906 cites W1986356667 @default.
• W2003023906 cites W1989877475 @default.
• W2003023906 cites W1992678959 @default.
• W2003023906 cites W1997257161 @default.
• W2003023906 cites W2016187294 @default.
• W2003023906 cites W2018322294 @default.
• W2003023906 cites W2018587471 @default.
• W2003023906 cites W2025036070 @default.
• W2003023906 cites W2028894362 @default.
• W2003023906 cites W2032856364 @default.
• W2003023906 cites W2036368914 @default.
• W2003023906 cites W2048574196 @default.
• W2003023906 cites W2065249968 @default.
• W2003023906 cites W2067431511 @default.
• W2003023906 cites W2068439521 @default.
• W2003023906 cites W2070379407 @default.
• W2003023906 cites W2077940064 @default.
• W2003023906 cites W2085167943 @default.
• W2003023906 cites W2090953855 @default.
• W2003023906 cites W2109734019 @default.
• W2003023906 cites W2127425177 @default.
• W2003023906 cites W2129866279 @default.
• W2003023906 doi "https://doi.org/10.1073/pnas.90.18.8415" @default.
• W2003023906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47367" @default.
• W2003023906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8378313" @default.
• W2003023906 hasPublicationYear "1993" @default.
• W2003023906 type Work @default.
• W2003023906 sameAs 2003023906 @default.
• W2003023906 citedByCount "24" @default.
• W2003023906 countsByYear W20030239062014 @default.
• W2003023906 crossrefType "journal-article" @default.
• W2003023906 hasAuthorship W2003023906A5014584657 @default.
• W2003023906 hasAuthorship W2003023906A5038557565 @default.
• W2003023906 hasAuthorship W2003023906A5043958921 @default.
• W2003023906 hasAuthorship W2003023906A5057574490 @default.
• W2003023906 hasAuthorship W2003023906A5058729669 @default.
• W2003023906 hasAuthorship W2003023906A5071933041 @default.
• W2003023906 hasAuthorship W2003023906A5072980336 @default.
• W2003023906 hasAuthorship W2003023906A5091653815 @default.
• W2003023906 hasBestOaLocation W20030239062 @default.
• W2003023906 hasConcept C129374314 @default.
• W2003023906 hasConcept C131665280 @default.
• W2003023906 hasConcept C147483822 @default.
• W2003023906 hasConcept C153911025 @default.
• W2003023906 hasConcept C154317977 @default.
• W2003023906 hasConcept C202751555 @default.
• W2003023906 hasConcept C203014093 @default.
• W2003023906 hasConcept C2776090121 @default.
• W2003023906 hasConcept C2780931953 @default.
• W2003023906 hasConcept C2908647359 @default.
• W2003023906 hasConcept C39347974 @default.
• W2003023906 hasConcept C55493867 @default.
• W2003023906 hasConcept C67662055 @default.
• W2003023906 hasConcept C71924100 @default.
• W2003023906 hasConcept C86803240 @default.
• W2003023906 hasConcept C8891405 @default.
• W2003023906 hasConcept C95444343 @default.
• W2003023906 hasConcept C99454951 @default.
• W2003023906 hasConceptScore W2003023906C129374314 @default.
• W2003023906 hasConceptScore W2003023906C131665280 @default.
• W2003023906 hasConceptScore W2003023906C147483822 @default.
• W2003023906 hasConceptScore W2003023906C153911025 @default.
• W2003023906 hasConceptScore W2003023906C154317977 @default.
• W2003023906 hasConceptScore W2003023906C202751555 @default.
• W2003023906 hasConceptScore W2003023906C203014093 @default.
• W2003023906 hasConceptScore W2003023906C2776090121 @default.
• W2003023906 hasConceptScore W2003023906C2780931953 @default.
• W2003023906 hasConceptScore W2003023906C2908647359 @default.
• W2003023906 hasConceptScore W2003023906C39347974 @default.
• W2003023906 hasConceptScore W2003023906C55493867 @default.
• W2003023906 hasConceptScore W2003023906C67662055 @default.
• W2003023906 hasConceptScore W2003023906C71924100 @default.
• W2003023906 hasConceptScore W2003023906C86803240 @default.
• W2003023906 hasConceptScore W2003023906C8891405 @default.
• W2003023906 hasConceptScore W2003023906C95444343 @default.
• W2003023906 hasConceptScore W2003023906C99454951 @default.

• next