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• W2003024744 abstract "Nischarin is a novel protein that regulates cell migration by inhibiting p21-activated kinase (PAK). LIM kinase (LIMK) is a downstream effector of PAK, and it is known to play an important role in cell invasion. Here we show that nischarin also associates with LIMK to inhibit LIMK activation, cofilin phosphorylation, and LIMK-mediated invasion of breast cancer cells, suggesting that nischarin regulates cell invasion by negative modulation of the LIMK/cofilin pathway. The amino terminus of nischarin binds to the PDZ and kinase domains of LIMK. Although LIMK activation enhances the interaction with nischarin, only phosphorylation of threonine 508 of LIMK is crucial for the interaction. Inhibition of endogenous nischarin expression by RNA interference stimulates breast cancer cell invasion. Also, nischarin small interfering RNA (siRNA) enhances cofilin phosphorylation. In addition, knock-down of nischarin showed branched projection actin structures. Collectively these data indicate that nischarin siRNA may enhance random migration, resulting in stimulation of invasion." @default.
• W2003024744 created "2016-06-24" @default.
• W2003024744 creator A5027297205 @default.
• W2003024744 creator A5049332865 @default.
• W2003024744 creator A5075895520 @default.
• W2003024744 date "2008-06-01" @default.
• W2003024744 modified "2023-09-27" @default.
• W2003024744 title "Nischarin Inhibits LIM Kinase To Regulate Cofilin Phosphorylation and Cell Invasion" @default.
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• W2003024744 doi "https://doi.org/10.1128/mcb.01832-07" @default.
• W2003024744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2423293" @default.
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