FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003034311> ?p ?o ?g. }

• W2003034311 endingPage "257" @default.
• W2003034311 startingPage "252" @default.
• W2003034311 abstract "Diabetes causes accelerated vascular dysfunction through mechanisms that are poorly understood. This study examined the role of Ca2+/calmodulin-dependent protein kinase II (CaMKII), Ras-GTPase and 20-hydroxyeicosatetraenoic acid (20-HETE) in the development of abnormal reactivity to vasoactive agents in the carotid artery of diabetic rats. The vasoconstrictor response induced by endothelin-1 (ET-1) was significantly increased, whereas vasodilator response to carbachol was significantly reduced in the carotid artery segments of the STZ-diabetic rats. In contrast, the vasoconstrictor response to depolarization of the carotid arterial rings with 50 mM KCl was similar in control and diabetic animals. Chronic intraperitoneal administration of KN-93 (5 mg/kg/alt diem), an inhibitor of CaMKII, FPTIII (1.5 mg/kg/alt diem), an inhibitor of Ras-GTPase, and inhibitors of 20-HETE formation 1-aminobenzotriazole (ABT, 50 mg/kg/alt diem) and N-hydroxy-N′-(4-butyl-2-methylphenyl)formamidine (HET0016, 2.5 mg/kg/day), produced significant normalization of the altered agonist-induced vasoconstrictor and vasodilator responses without affecting blood glucose levels. All the inhibitors were administered for 4 weeks starting from the day 1 of diabetes induction. Inhibition of CaMKII, Ras-GTPase or 20-HETE formation did not affect the agonist-induced vasoconstrictor and vasodilator responses in the non-diabetic control animals. These data indicate that chronic blockade of CaMKII, Ras-GTPase or the production of 20-HETE normalizes the altered vascular reactivity to ET-1 and carbachol in the carotid artery of STZ-induced diabetic rats." @default.
• W2003034311 created "2016-06-24" @default.
• W2003034311 creator A5012210618 @default.
• W2003034311 creator A5030171307 @default.
• W2003034311 creator A5062833068 @default.
• W2003034311 creator A5072044290 @default.
• W2003034311 date "2005-09-01" @default.
• W2003034311 modified "2023-09-24" @default.
• W2003034311 title "Inhibition of Ca/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery" @default.
• W2003034311 cites W1554444467 @default.
• W2003034311 cites W1913730804 @default.
• W2003034311 cites W1967622958 @default.
• W2003034311 cites W1976442813 @default.
• W2003034311 cites W1978668304 @default.
• W2003034311 cites W1981722424 @default.
• W2003034311 cites W1983693804 @default.
• W2003034311 cites W1984924898 @default.
• W2003034311 cites W1995142464 @default.
• W2003034311 cites W1997045912 @default.
• W2003034311 cites W2000625731 @default.
• W2003034311 cites W2025458248 @default.
• W2003034311 cites W2028238005 @default.
• W2003034311 cites W2036411319 @default.
• W2003034311 cites W2039861539 @default.
• W2003034311 cites W2049872761 @default.
• W2003034311 cites W2053365438 @default.
• W2003034311 cites W2054113090 @default.
• W2003034311 cites W2082565818 @default.
• W2003034311 cites W2083990676 @default.
• W2003034311 cites W2097702993 @default.
• W2003034311 cites W2102962566 @default.
• W2003034311 cites W2115191605 @default.
• W2003034311 cites W2122074407 @default.
• W2003034311 cites W2123650541 @default.
• W2003034311 cites W2124308915 @default.
• W2003034311 cites W2139451284 @default.
• W2003034311 cites W2139918198 @default.
• W2003034311 cites W2144874605 @default.
• W2003034311 cites W2161881338 @default.
• W2003034311 cites W2162766735 @default.
• W2003034311 cites W2170794217 @default.
• W2003034311 cites W2276469817 @default.
• W2003034311 cites W2342067684 @default.
• W2003034311 cites W2395568034 @default.
• W2003034311 cites W2413356861 @default.
• W2003034311 cites W89103658 @default.
• W2003034311 doi "https://doi.org/10.1016/j.phrs.2005.04.001" @default.
• W2003034311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15886012" @default.
• W2003034311 hasPublicationYear "2005" @default.
• W2003034311 type Work @default.
• W2003034311 sameAs 2003034311 @default.
• W2003034311 citedByCount "37" @default.
• W2003034311 countsByYear W20030343112013 @default.
• W2003034311 countsByYear W20030343112014 @default.
• W2003034311 countsByYear W20030343112015 @default.
• W2003034311 countsByYear W20030343112016 @default.
• W2003034311 countsByYear W20030343112017 @default.
• W2003034311 countsByYear W20030343112018 @default.
• W2003034311 countsByYear W20030343112020 @default.
• W2003034311 countsByYear W20030343112021 @default.
• W2003034311 countsByYear W20030343112022 @default.
• W2003034311 crossrefType "journal-article" @default.
• W2003034311 hasAuthorship W2003034311A5012210618 @default.
• W2003034311 hasAuthorship W2003034311A5030171307 @default.
• W2003034311 hasAuthorship W2003034311A5062833068 @default.
• W2003034311 hasAuthorship W2003034311A5072044290 @default.
• W2003034311 hasConcept C120770815 @default.
• W2003034311 hasConcept C126322002 @default.
• W2003034311 hasConcept C134018914 @default.
• W2003034311 hasConcept C170493617 @default.
• W2003034311 hasConcept C185592680 @default.
• W2003034311 hasConcept C2777093181 @default.
• W2003034311 hasConcept C2778988552 @default.
• W2003034311 hasConcept C55493867 @default.
• W2003034311 hasConcept C62478195 @default.
• W2003034311 hasConcept C71924100 @default.
• W2003034311 hasConceptScore W2003034311C120770815 @default.
• W2003034311 hasConceptScore W2003034311C126322002 @default.
• W2003034311 hasConceptScore W2003034311C134018914 @default.
• W2003034311 hasConceptScore W2003034311C170493617 @default.
• W2003034311 hasConceptScore W2003034311C185592680 @default.
• W2003034311 hasConceptScore W2003034311C2777093181 @default.
• W2003034311 hasConceptScore W2003034311C2778988552 @default.
• W2003034311 hasConceptScore W2003034311C55493867 @default.
• W2003034311 hasConceptScore W2003034311C62478195 @default.
• W2003034311 hasConceptScore W2003034311C71924100 @default.
• W2003034311 hasIssue "3" @default.
• W2003034311 hasLocation W20030343111 @default.
• W2003034311 hasOpenAccess W2003034311 @default.
• W2003034311 hasPrimaryLocation W20030343111 @default.
• W2003034311 hasRelatedWork W1901275661 @default.
• W2003034311 hasRelatedWork W1972099714 @default.
• W2003034311 hasRelatedWork W1986343589 @default.
• W2003034311 hasRelatedWork W2022685867 @default.
• W2003034311 hasRelatedWork W2039848084 @default.
• W2003034311 hasRelatedWork W2040046061 @default.
• W2003034311 hasRelatedWork W2048823012 @default.
• W2003034311 hasRelatedWork W2057576900 @default.

• next