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• W2003040070 abstract "Heme oxygenase (HO)-1 degrades heme and protects against oxidative stress, but it has not been pharmacologically induced in humans. In this randomized study of 10 healthy volunteers, hemin (3 mg/kg intravenously in 25% albumin) was shown to increase plasma HO-1 protein concentration four- to fivefold and HO-1 activity ~15-fold relative to baseline at 24 and 48 h (placebo -56.41 +/- 6.31 (baseline), 69.79 +/- 13.00 (24 h), 77.44 +/- 10.62 (48 h) vs. hemin -71.70 +/- 9.20 (baseline), 1,126.20 +/- 293.30 (24 h), 1,192.20 +/- 333.30 (48 h)) in four of five subjects as compared with albumin alone (P </= 0.03). This represents the overcoming of a fundamental hurdle to HO-1 research in humans." @default.
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• W2003040070 date "2009-12-02" @default.
• W2003040070 modified "2023-10-01" @default.
• W2003040070 title "First-in-Human Study Demonstrating Pharmacological Activation of Heme Oxygenase-1 in Humans" @default.
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• W2003040070 doi "https://doi.org/10.1038/clpt.2009.221" @default.
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