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- W2003048183 abstract "The importance of adjusting the dosage of isoniazid and of streptomycin administered to tuberculous patients so that at least a 0·4 μg./ml. serum level of isoniazid and 20 μg./ml. serum level of streptomycin be concomitantly achieved is discussed. The results of microbiologic assays for antimicrobially active isoniazid and streptomycin serum levels in a group of 1,010 tuberculous patients are presented. About 30 per cent of a group of 744 patients failed to achieve the estimated minimal isoniazid level consistent with total sterilization of all multiplying catalase-positive (isoniazid-susceptible and weakly isoniazid-resistant) tubercle bacilli after a loading dose of 4 mg. isoniazid per kg. body weight; the increase of the loading dose to 8 mg. isoniazid per kg. body weight still left 20 per cent of a group of 633 patients with a serum level below 0·4 μg./ml. The loading dose was calculated as half the total projected daily dosage of isoniazid. Thirty per cent of a group of 501 patients failed to achieve the estimated necessary serum level (20μg./ml. serum) six hours after an intramuscular injection of 20 mg. streptomycin sulfate per kg. body weight. It is concluded that the only way to assure an optimal isoniazid and streptomycin concentration at the sites of bacterial multiplication in tuberculous patients without increasing unnecessarily the incidence of toxic side-effects is to ‘tailor’ these drugs' dosages according to the individual patient's metabolic rate of inactivation of isoniazid and renal clearance of streptomycin. These rates can be determined by properly performed microbiologic assays for antimicrobially active serum isoniazid and streptomycin concentrations." @default.
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- W2003048183 title "Dosages of isoniazid and streptomycin for routine chemotherapy of tuberculosis" @default.
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- W2003048183 doi "https://doi.org/10.1016/s0041-3879(60)80020-7" @default.
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