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• W2003054328 abstract "Here, we report on the successful programming of dendritic cells (DCs) using selectively applied mixtures of chemokines as a novel protocol for engineering vaccine efficiency. Antigen internalization by DCs is a pivotal step in antigen uptake/presentation for bridging innate and adaptive immunity and in exogenous gene delivery used in vaccine strategies. Contrary to most approaches to improve vaccine efficiency, active enhancement of antigen internalization by DCs as a vaccine strategy has been less studied because DCs naturally down-regulate antigen internalization upon maturation. Whereas chemokines are mainly known as signal proteins that induce leucocyte chemotaxis, very little research has been carried out to identify any additional effects of chemokines on DCs following maturation. Here, immature DCs are pre-treated with select chemokines before intentional maturation using lipopolysaccharide (LPS). When pre-treated with a mixture of CCL3 and CCL19 in a 7 : 3 ratio, then matured with LPS, chemokine pre-treated DCs exhibited 36% higher antigen uptake capacity than immature DCs and 27% higher antigen-processing capacity than immature DCs treated only with LPS. Further, CCL3 : CCL19 (7 : 3) pre-treatment of DCs modulated MHC molecule expression and secretion of various cytokines of DCs. Collectively, DC programming was feasible using a specific chemokine combination and these results provide a novel strategy for enhancing DC-based vaccine efficiency. In Part II, we report on the phenotype changes and antigen presentation capacity of chemokine pre-treated murine bone marrow-derived DCs examined in long-term co-culture with antigen-specific CD4(+) T cells." @default.
• W2003054328 created "2016-06-24" @default.
• W2003054328 creator A5015868285 @default.
• W2003054328 creator A5016772255 @default.
• W2003054328 creator A5088467357 @default.
• W2003054328 date "2013-04-08" @default.
• W2003054328 modified "2023-09-26" @default.
• W2003054328 title "Chemokine programming dendritic cell antigen response: part I - select chemokine programming of antigen uptake even after maturation" @default.
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• W2003054328 doi "https://doi.org/10.1111/imm.12056" @default.
• W2003054328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3634540" @default.
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• W2003054328 hasPublicationYear "2013" @default.
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