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- W2003059037 abstract "Abstract Objectives Widespread sensory hypersensitivity has been observed in acute whiplash associated disorders ( WAD ). Changes in descending pain modulation take part in central sensitization. However, endogenous pain modulation has never been investigated in acute WAD . Altered perception of distorted visual feedback has been observed in WAD . Both mechanisms (ie, pain modulation and perception of distorted visual feedback) may be different components of one integrated system orchestrated by the brain. This study evaluated conditioned pain modulation ( CPM ) in acute WAD . Secondly, we investigated whether changes in CPM are associated with altered perception of distorted visual feedback. Methods Thirty patients with acute WAD , 35 patients with chronic WAD and 31 controls were subjected to an experiment evaluating CPM and a coordination task inducing visual mediated changes between sensory feedback and motor output. Results A significant CPM effect was observed in acute WAD ( P = 0.012 and P = 0.006), which was significantly lower compared to controls ( P = 0.004 and P = 0.020). No obvious differences in CPM were found between acute and chronic WAD ( P = 0.098 and P = 0.041). Changes in CPM were unrelated to altered perception of distorted visual feedback ( P > 0.01). Conclusion Changes in CPM were observed in acute WAD , suggesting less efficient pain modulation. The results suggest that central pain and sensorimotor processing underlie distinctive mechanisms." @default.
- W2003059037 created "2016-06-24" @default.
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- W2003059037 date "2013-09-30" @default.
- W2003059037 modified "2023-10-02" @default.
- W2003059037 title "Changes in Pain Modulation Occur Soon After Whiplash Trauma but are not Related to Altered Perception of Distorted Visual Feedback" @default.
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- W2003059037 doi "https://doi.org/10.1111/papr.12113" @default.
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