FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003059178> ?p ?o ?g. }

• W2003059178 endingPage "S250" @default.
• W2003059178 startingPage "S250" @default.
• W2003059178 abstract "RationaleFood allergy is a common disease that often causes anaphylaxis. The diagnosis is problematic. 20% of the population believe they have food allergy when only 2% are diagnosed with IgE mediated allergy response. In this study we use basophile response to allergen to diagnose food allergy.MethodsWe investigated atopic subjects with (n = 5) or without (n = 3) peanut allergy. Whole blood was mixed with peanut allergen or negative control and specific fluorescence labelled mouse antibodies against CD63 and CD203c. The response was evaluated in flow cytometry (basophile activation test/BAT). IgE allergy responses were also tested with immunoCAP method (Pharmacia) and skin prick tests (SPT) (Greer).ResultsRatio of positively labelled cells in the BAT test increased significantly, from 4.19 ± 0.6% to 60.88 ± 31.9% (p = 0.008) for those who had peanut allergy but not for the control group, (from 4,22 ± 0,75% to 7,43 ± 5,05% (p = 0,700). Significant correlation was found between BAT and SPT (R = 0,817; p = 0,013) but correlation between BAT and specific IgE was not significant (R = 0,602; p = 0,102). Specificity and sensitivity for each test when compared with allergist diagnosed peanut allergy was 100% and 100% for BAT, 100% and 83% for SPT, 75% and 100% for IgE >0.35 kUA/L and 100% and 56% for IgE >15 kUA/L, respectively.ConclusionThe basophile activation test is helpful in diagnosing peanut allergy and demonstrated in this study higher specificity and sensitivity rates than skin prick test and IgE measured with immunoCAP. RationaleFood allergy is a common disease that often causes anaphylaxis. The diagnosis is problematic. 20% of the population believe they have food allergy when only 2% are diagnosed with IgE mediated allergy response. In this study we use basophile response to allergen to diagnose food allergy. Food allergy is a common disease that often causes anaphylaxis. The diagnosis is problematic. 20% of the population believe they have food allergy when only 2% are diagnosed with IgE mediated allergy response. In this study we use basophile response to allergen to diagnose food allergy. MethodsWe investigated atopic subjects with (n = 5) or without (n = 3) peanut allergy. Whole blood was mixed with peanut allergen or negative control and specific fluorescence labelled mouse antibodies against CD63 and CD203c. The response was evaluated in flow cytometry (basophile activation test/BAT). IgE allergy responses were also tested with immunoCAP method (Pharmacia) and skin prick tests (SPT) (Greer). We investigated atopic subjects with (n = 5) or without (n = 3) peanut allergy. Whole blood was mixed with peanut allergen or negative control and specific fluorescence labelled mouse antibodies against CD63 and CD203c. The response was evaluated in flow cytometry (basophile activation test/BAT). IgE allergy responses were also tested with immunoCAP method (Pharmacia) and skin prick tests (SPT) (Greer). ResultsRatio of positively labelled cells in the BAT test increased significantly, from 4.19 ± 0.6% to 60.88 ± 31.9% (p = 0.008) for those who had peanut allergy but not for the control group, (from 4,22 ± 0,75% to 7,43 ± 5,05% (p = 0,700). Significant correlation was found between BAT and SPT (R = 0,817; p = 0,013) but correlation between BAT and specific IgE was not significant (R = 0,602; p = 0,102). Specificity and sensitivity for each test when compared with allergist diagnosed peanut allergy was 100% and 100% for BAT, 100% and 83% for SPT, 75% and 100% for IgE >0.35 kUA/L and 100% and 56% for IgE >15 kUA/L, respectively. Ratio of positively labelled cells in the BAT test increased significantly, from 4.19 ± 0.6% to 60.88 ± 31.9% (p = 0.008) for those who had peanut allergy but not for the control group, (from 4,22 ± 0,75% to 7,43 ± 5,05% (p = 0,700). Significant correlation was found between BAT and SPT (R = 0,817; p = 0,013) but correlation between BAT and specific IgE was not significant (R = 0,602; p = 0,102). Specificity and sensitivity for each test when compared with allergist diagnosed peanut allergy was 100% and 100% for BAT, 100% and 83% for SPT, 75% and 100% for IgE >0.35 kUA/L and 100% and 56% for IgE >15 kUA/L, respectively. ConclusionThe basophile activation test is helpful in diagnosing peanut allergy and demonstrated in this study higher specificity and sensitivity rates than skin prick test and IgE measured with immunoCAP. The basophile activation test is helpful in diagnosing peanut allergy and demonstrated in this study higher specificity and sensitivity rates than skin prick test and IgE measured with immunoCAP." @default.
• W2003059178 created "2016-06-24" @default.
• W2003059178 creator A5063313183 @default.
• W2003059178 creator A5063553309 @default.
• W2003059178 creator A5069081521 @default.
• W2003059178 creator A5073049526 @default.
• W2003059178 creator A5074446725 @default.
• W2003059178 date "2008-02-01" @default.
• W2003059178 modified "2023-09-27" @default.
• W2003059178 title "Basophil Activation Test for Diagnosis of Food Allergy" @default.
• W2003059178 doi "https://doi.org/10.1016/j.jaci.2007.12.989" @default.
• W2003059178 hasPublicationYear "2008" @default.
• W2003059178 type Work @default.
• W2003059178 sameAs 2003059178 @default.
• W2003059178 citedByCount "0" @default.
• W2003059178 crossrefType "journal-article" @default.
• W2003059178 hasAuthorship W2003059178A5063313183 @default.
• W2003059178 hasAuthorship W2003059178A5063553309 @default.
• W2003059178 hasAuthorship W2003059178A5069081521 @default.
• W2003059178 hasAuthorship W2003059178A5073049526 @default.
• W2003059178 hasAuthorship W2003059178A5074446725 @default.
• W2003059178 hasBestOaLocation W20030591781 @default.
• W2003059178 hasConcept C104317684 @default.
• W2003059178 hasConcept C141105273 @default.
• W2003059178 hasConcept C145059251 @default.
• W2003059178 hasConcept C159654299 @default.
• W2003059178 hasConcept C203014093 @default.
• W2003059178 hasConcept C20518536 @default.
• W2003059178 hasConcept C207480886 @default.
• W2003059178 hasConcept C2776027960 @default.
• W2003059178 hasConcept C2776385711 @default.
• W2003059178 hasConcept C2777456892 @default.
• W2003059178 hasConcept C2778012357 @default.
• W2003059178 hasConcept C2779176990 @default.
• W2003059178 hasConcept C2780510475 @default.
• W2003059178 hasConcept C2908647359 @default.
• W2003059178 hasConcept C55493867 @default.
• W2003059178 hasConcept C71924100 @default.
• W2003059178 hasConcept C86803240 @default.
• W2003059178 hasConcept C99454951 @default.
• W2003059178 hasConceptScore W2003059178C104317684 @default.
• W2003059178 hasConceptScore W2003059178C141105273 @default.
• W2003059178 hasConceptScore W2003059178C145059251 @default.
• W2003059178 hasConceptScore W2003059178C159654299 @default.
• W2003059178 hasConceptScore W2003059178C203014093 @default.
• W2003059178 hasConceptScore W2003059178C20518536 @default.
• W2003059178 hasConceptScore W2003059178C207480886 @default.
• W2003059178 hasConceptScore W2003059178C2776027960 @default.
• W2003059178 hasConceptScore W2003059178C2776385711 @default.
• W2003059178 hasConceptScore W2003059178C2777456892 @default.
• W2003059178 hasConceptScore W2003059178C2778012357 @default.
• W2003059178 hasConceptScore W2003059178C2779176990 @default.
• W2003059178 hasConceptScore W2003059178C2780510475 @default.
• W2003059178 hasConceptScore W2003059178C2908647359 @default.
• W2003059178 hasConceptScore W2003059178C55493867 @default.
• W2003059178 hasConceptScore W2003059178C71924100 @default.
• W2003059178 hasConceptScore W2003059178C86803240 @default.
• W2003059178 hasConceptScore W2003059178C99454951 @default.
• W2003059178 hasIssue "2" @default.
• W2003059178 hasLocation W20030591781 @default.
• W2003059178 hasOpenAccess W2003059178 @default.
• W2003059178 hasPrimaryLocation W20030591781 @default.
• W2003059178 hasRelatedWork W1579441494 @default.
• W2003059178 hasRelatedWork W1994983944 @default.
• W2003059178 hasRelatedWork W2026004875 @default.
• W2003059178 hasRelatedWork W2041473883 @default.
• W2003059178 hasRelatedWork W2079042690 @default.
• W2003059178 hasRelatedWork W2079868760 @default.
• W2003059178 hasRelatedWork W2091469647 @default.
• W2003059178 hasRelatedWork W2162823880 @default.
• W2003059178 hasRelatedWork W2170036507 @default.
• W2003059178 hasRelatedWork W3112609006 @default.
• W2003059178 hasVolume "121" @default.
• W2003059178 isParatext "false" @default.
• W2003059178 isRetracted "false" @default.
• W2003059178 magId "2003059178" @default.
• W2003059178 workType "article" @default.