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• W2003060263 abstract "Pancreatic cancer is a leading cause of cancer-related deaths in men and women. Early clinical studies suggest that photodynamic therapy (PDT) might be a useful modality in the management of this deadly disease. In this study, the photocytotoxicity of Photofrin-mediated PDT on different human pancreatic cancer cells (BxPc-3, HPAF-II, Mia PaCa-2, MPanc-96, PANC-1 and PL-45) was examined. After co-incubating cancer cells with Photofrin (0–10 μg/ml) for 4 h, the cells were irradiated with 0–6 J/cm2 of 630 nm light. The effect of Photofrin PDT on the survival of cells were examined using tetrazolium-based colorimetric assay and clonogenic assay. PDT-induced apoptosis was analyzed by flow cytometry. Expressions of apoptosis-related proteins were determined by western blot analysis. Photofrin PDT strongly inhibited the survival of pancreatic cancer cells. A small portion of cells (<15%) underwent apoptosis 24 h after PDT at LD50. Cleavage of caspase-3, caspase-8, caspase-9 and PARP after PDT were also confirmed. BxPc-3, Mia PaCa-2, MPanc-96, and PANC-1 cells were more sensitive and HPAF-II and PL-45 cells less sensitive. Photofrin PDT can induce apoptosis and inhibit survival of human pancreatic cancer cells." @default.
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• W2003060263 date "2013-09-01" @default.
• W2003060263 modified "2023-10-17" @default.
• W2003060263 title "Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells" @default.
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• W2003060263 doi "https://doi.org/10.1016/j.pdpdt.2012.11.001" @default.
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