Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003060606> ?p ?o ?g. }
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- W2003060606 abstract "Mitogen-activated protein kinase (MAPK) pathways constitute a large modular network that regulates a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. The function of the ERK pathway has been depicted as survival-promoting, in essence by opposing the proapoptotic activity of the stress-activated c-Jun NH(2)-terminal kinase (JNK)/p38 MAPK pathways. However, recently published work suggests that extracellular regulated kinase (ERK) pathway activity is suppressed by JNK/p38 kinases during apoptosis induction. In this review, we will summarize the current knowledge about JNK/p38-mediated mechanisms that negatively regulate the ERK pathway. In particular, we will focus on phosphatases (PP2A, MKPs) as inhibitors of ERK pathway activity in regulating apoptosis. A model proposed in this review places the negative regulation of the ERK pathway in a central position for the cellular decision-making process that determines whether cells will live or die in response to apoptosis-promoting signals. In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation)." @default.
- W2003060606 created "2016-06-24" @default.
- W2003060606 creator A5008528112 @default.
- W2003060606 creator A5032153203 @default.
- W2003060606 creator A5040110214 @default.
- W2003060606 date "2007-11-26" @default.
- W2003060606 modified "2023-10-02" @default.
- W2003060606 title "Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival" @default.
- W2003060606 cites W1494491432 @default.
- W2003060606 cites W1503780223 @default.
- W2003060606 cites W1518252063 @default.
- W2003060606 cites W1521417371 @default.
- W2003060606 cites W1530284699 @default.
- W2003060606 cites W1536338485 @default.
- W2003060606 cites W1538631790 @default.
- W2003060606 cites W1551845545 @default.
- W2003060606 cites W1556080027 @default.
- W2003060606 cites W1823288226 @default.
- W2003060606 cites W1964504843 @default.
- W2003060606 cites W1965343041 @default.
- W2003060606 cites W1967218150 @default.
- W2003060606 cites W1971626394 @default.
- W2003060606 cites W1976385326 @default.
- W2003060606 cites W1976441097 @default.
- W2003060606 cites W1977599918 @default.
- W2003060606 cites W1980272041 @default.
- W2003060606 cites W1981076681 @default.
- W2003060606 cites W1983475354 @default.
- W2003060606 cites W1983833034 @default.
- W2003060606 cites W1986214532 @default.
- W2003060606 cites W1988862655 @default.
- W2003060606 cites W1990065094 @default.
- W2003060606 cites W1991196199 @default.
- W2003060606 cites W1991605733 @default.
- W2003060606 cites W1991667983 @default.
- W2003060606 cites W1994219871 @default.
- W2003060606 cites W1995168933 @default.
- W2003060606 cites W1995205975 @default.
- W2003060606 cites W1998809668 @default.
- W2003060606 cites W1999207367 @default.
- W2003060606 cites W2000817203 @default.
- W2003060606 cites W2001617515 @default.
- W2003060606 cites W2002663964 @default.
- W2003060606 cites W2004143904 @default.
- W2003060606 cites W2006020460 @default.
- W2003060606 cites W2007072099 @default.
- W2003060606 cites W2007986629 @default.
- W2003060606 cites W2011826559 @default.
- W2003060606 cites W2012440244 @default.
- W2003060606 cites W2013149045 @default.
- W2003060606 cites W2016364696 @default.
- W2003060606 cites W2017958579 @default.
- W2003060606 cites W2018656850 @default.
- W2003060606 cites W2025872894 @default.
- W2003060606 cites W2026894807 @default.
- W2003060606 cites W2028083348 @default.
- W2003060606 cites W2029962841 @default.
- W2003060606 cites W2031108838 @default.
- W2003060606 cites W2033443838 @default.
- W2003060606 cites W2035743526 @default.
- W2003060606 cites W2037250704 @default.
- W2003060606 cites W2042921323 @default.
- W2003060606 cites W2043617798 @default.
- W2003060606 cites W2044419584 @default.
- W2003060606 cites W2044481116 @default.
- W2003060606 cites W2045251540 @default.
- W2003060606 cites W2048217255 @default.
- W2003060606 cites W2049277771 @default.
- W2003060606 cites W2050085273 @default.
- W2003060606 cites W2050252881 @default.
- W2003060606 cites W2051201358 @default.
- W2003060606 cites W2053718673 @default.
- W2003060606 cites W2054292493 @default.
- W2003060606 cites W2055241999 @default.
- W2003060606 cites W2057364858 @default.
- W2003060606 cites W2059925297 @default.
- W2003060606 cites W2059937375 @default.
- W2003060606 cites W2060163314 @default.
- W2003060606 cites W2063501226 @default.
- W2003060606 cites W2065285374 @default.
- W2003060606 cites W2066060839 @default.
- W2003060606 cites W2070330987 @default.
- W2003060606 cites W2072243374 @default.
- W2003060606 cites W2074089133 @default.
- W2003060606 cites W2074189563 @default.
- W2003060606 cites W2075150275 @default.
- W2003060606 cites W2076485183 @default.
- W2003060606 cites W2080832123 @default.
- W2003060606 cites W2081527131 @default.
- W2003060606 cites W2083875726 @default.
- W2003060606 cites W2086981199 @default.
- W2003060606 cites W2089884711 @default.
- W2003060606 cites W2089896836 @default.
- W2003060606 cites W2091864083 @default.
- W2003060606 cites W2095169768 @default.
- W2003060606 cites W2096693902 @default.
- W2003060606 cites W2099800698 @default.
- W2003060606 cites W2101803513 @default.