FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003060888> ?p ?o ?g. }

• W2003060888 abstract "An important aspect of proteomic mass spectrometry involves quantifying and interpreting the isotope distributions arising from mixtures of macromolecules with different isotope labeling patterns. These patterns can be quite complex, in particular with in vivo metabolic labeling experiments producing fractional atomic labeling or fractional residue labeling of peptides or other macromolecules. In general, it can be difficult to distinguish the contributions of species with different labeling patterns to an experimental spectrum and difficult to calculate a theoretical isotope distribution to fit such data. There is a need for interactive and user-friendly software that can calculate and fit the entire isotope distribution of a complex mixture while comparing these calculations with experimental data and extracting the contributions from the differently labeled species. Envelope has been developed to be user-friendly while still being as flexible and powerful as possible. Envelope can simultaneously calculate the isotope distributions for any number of different labeling patterns for a given peptide or oligonucleotide, while automatically summing these into a single overall isotope distribution. Envelope can handle fractional or complete atom or residue-based labeling, and the contribution from each different user-defined labeling pattern is clearly illustrated in the interactive display and is individually adjustable. At present, Envelope supports labeling with 2H, 13C, and 15N, and supports adjustments for baseline correction, an instrument accuracy offset in the m/z domain, and peak width. Furthermore, Envelope can display experimental data superimposed on calculated isotope distributions, and calculate a least-squares goodness of fit between the two. All of this information is displayed on the screen in a single graphical user interface. Envelope supports high-quality output of experimental and calculated distributions in PNG or PDF format. Beyond simply comparing calculated distributions to experimental data, Envelope is useful for planning or designing metabolic labeling experiments, by visualizing hypothetical isotope distributions in order to evaluate the feasibility of a labeling strategy. Envelope is also useful as a teaching tool, with its real-time display capabilities providing a straightforward way to illustrate the key variable factors that contribute to an observed isotope distribution. Envelope is a powerful tool for the interactive calculation and visualization of complex isotope distributions for comparison to experimental data. It is available under the GNU General Public License from http://williamson.scripps.edu/envelope/ ." @default.
• W2003060888 created "2016-06-24" @default.
• W2003060888 creator A5057209571 @default.
• W2003060888 creator A5074143608 @default.
• W2003060888 date "2008-10-20" @default.
• W2003060888 modified "2023-10-11" @default.
• W2003060888 title "Envelope: interactive software for modeling and fitting complex isotope distributions" @default.
• W2003060888 cites W1964010911 @default.
• W2003060888 cites W1973563015 @default.
• W2003060888 cites W1975938671 @default.
• W2003060888 cites W1978769064 @default.
• W2003060888 cites W2003763500 @default.
• W2003060888 cites W2006481826 @default.
• W2003060888 cites W2013215411 @default.
• W2003060888 cites W2017259594 @default.
• W2003060888 cites W2042804085 @default.
• W2003060888 cites W2044655708 @default.
• W2003060888 cites W2052388444 @default.
• W2003060888 cites W2053539821 @default.
• W2003060888 cites W2075326868 @default.
• W2003060888 cites W2102182691 @default.
• W2003060888 cites W2107231094 @default.
• W2003060888 cites W2114754207 @default.
• W2003060888 cites W2124114991 @default.
• W2003060888 cites W2132899146 @default.
• W2003060888 cites W2135817903 @default.
• W2003060888 cites W2140417870 @default.
• W2003060888 cites W2150931449 @default.
• W2003060888 cites W2158447287 @default.
• W2003060888 cites W2165721436 @default.
• W2003060888 doi "https://doi.org/10.1186/1471-2105-9-446" @default.
• W2003060888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2605472" @default.
• W2003060888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18937869" @default.
• W2003060888 hasPublicationYear "2008" @default.
• W2003060888 type Work @default.
• W2003060888 sameAs 2003060888 @default.
• W2003060888 citedByCount "10" @default.
• W2003060888 countsByYear W20030608882013 @default.
• W2003060888 countsByYear W20030608882014 @default.
• W2003060888 countsByYear W20030608882017 @default.
• W2003060888 countsByYear W20030608882019 @default.
• W2003060888 crossrefType "journal-article" @default.
• W2003060888 hasAuthorship W2003060888A5057209571 @default.
• W2003060888 hasAuthorship W2003060888A5074143608 @default.
• W2003060888 hasBestOaLocation W20030608881 @default.
• W2003060888 hasConcept C11413529 @default.
• W2003060888 hasConcept C121332964 @default.
• W2003060888 hasConcept C124101348 @default.
• W2003060888 hasConcept C164304813 @default.
• W2003060888 hasConcept C178790620 @default.
• W2003060888 hasConcept C185544564 @default.
• W2003060888 hasConcept C185592680 @default.
• W2003060888 hasConcept C186060115 @default.
• W2003060888 hasConcept C199360897 @default.
• W2003060888 hasConcept C2777904410 @default.
• W2003060888 hasConcept C36674120 @default.
• W2003060888 hasConcept C41008148 @default.
• W2003060888 hasConcept C554190296 @default.
• W2003060888 hasConcept C65155139 @default.
• W2003060888 hasConcept C76155785 @default.
• W2003060888 hasConcept C86803240 @default.
• W2003060888 hasConceptScore W2003060888C11413529 @default.
• W2003060888 hasConceptScore W2003060888C121332964 @default.
• W2003060888 hasConceptScore W2003060888C124101348 @default.
• W2003060888 hasConceptScore W2003060888C164304813 @default.
• W2003060888 hasConceptScore W2003060888C178790620 @default.
• W2003060888 hasConceptScore W2003060888C185544564 @default.
• W2003060888 hasConceptScore W2003060888C185592680 @default.
• W2003060888 hasConceptScore W2003060888C186060115 @default.
• W2003060888 hasConceptScore W2003060888C199360897 @default.
• W2003060888 hasConceptScore W2003060888C2777904410 @default.
• W2003060888 hasConceptScore W2003060888C36674120 @default.
• W2003060888 hasConceptScore W2003060888C41008148 @default.
• W2003060888 hasConceptScore W2003060888C554190296 @default.
• W2003060888 hasConceptScore W2003060888C65155139 @default.
• W2003060888 hasConceptScore W2003060888C76155785 @default.
• W2003060888 hasConceptScore W2003060888C86803240 @default.
• W2003060888 hasIssue "1" @default.
• W2003060888 hasLocation W20030608881 @default.
• W2003060888 hasLocation W20030608882 @default.
• W2003060888 hasLocation W20030608883 @default.
• W2003060888 hasLocation W20030608884 @default.
• W2003060888 hasOpenAccess W2003060888 @default.
• W2003060888 hasPrimaryLocation W20030608881 @default.
• W2003060888 hasRelatedWork W1966947548 @default.
• W2003060888 hasRelatedWork W2029815040 @default.
• W2003060888 hasRelatedWork W2073227694 @default.
• W2003060888 hasRelatedWork W2080320374 @default.
• W2003060888 hasRelatedWork W2115672549 @default.
• W2003060888 hasRelatedWork W2883559753 @default.
• W2003060888 hasRelatedWork W2886289776 @default.
• W2003060888 hasRelatedWork W2983473129 @default.
• W2003060888 hasRelatedWork W4328027404 @default.
• W2003060888 hasRelatedWork W4367147823 @default.
• W2003060888 hasVolume "9" @default.
• W2003060888 isParatext "false" @default.
• W2003060888 isRetracted "false" @default.
• W2003060888 magId "2003060888" @default.
• W2003060888 workType "article" @default.