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• W2003061036 abstract "Several novel alkylidene branched lupane derivatives have been prepared. Many of these compounds showed a significant cytotoxicity. The most active compound, 2-methylene-betulonic acid, showed IC(50) values between 0.2 and 0.6 μM for 15 different human cancer cell lines. Cytotoxicity can be improved by encapsulation in liposomes. These compounds act by triggering apoptotic cell death as shown by DNA-laddering experiments and acridine orange/ethidium bromide staining." @default.
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• W2003061036 date "2012-07-01" @default.
• W2003061036 modified "2023-10-14" @default.
• W2003061036 title "Alkylidene branched lupane derivatives: Synthesis and antitumor activity" @default.
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• W2003061036 doi "https://doi.org/10.1016/j.ejmech.2012.04.023" @default.
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