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- W2003068819 abstract "Chromosomal abnormalities have been observed in lymphosarcomas of AKR and AKR/T1ALD mice. AKR/T1AlD is a substrain of AKR in which a translocation occurred spontaneously, so that its chromosomal number is 38, 36 acrocentric chromosomes and 2 metacentrics, instead of 40 acrocentrics in AKR. Lymphosarcomas have been studied in animals unirradiated and exposed to sub-lethal fractionated irradiation or whole-body acute irradiation. The most frequent abnormality is an extra additional metacentric very often identical to the normal pair and probably originating from a non-disjunction. This trisomy is characteristic of leukaemic cells as it has never been found in normal mice. Its frequency is comparable with that of additional acrocentrics in AKR and quite independent of irradiation, as it is the same in control (25%) and in irradiated T1ALD mice (26·7%)." @default.
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- W2003068819 date "1971-12-01" @default.
- W2003068819 modified "2023-09-25" @default.
- W2003068819 title "Chromosome abnormalities in AKR/T1ALD leukaemias" @default.
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- W2003068819 doi "https://doi.org/10.1016/0014-2964(71)90051-x" @default.
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