FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003069632> ?p ?o ?g. }

• W2003069632 endingPage "219" @default.
• W2003069632 startingPage "211" @default.
• W2003069632 abstract "Purpose: The aims of this experimental work were the incorporation and full characterization of the system Tretinoin-in-dimethyl-beta-cyclodextrin-in-ultradeformable vesicles (Tretinoin-CyD-UDV) and Tretinoin-in-ultradeformable vesicles (Tretinoin-UDV).Methods: The Tretinoin-CyD complex was prepared by kneading and the UDV by adding soybean phosphatidylcholine (SPC) to Tween® 80 followed by an appropriate volume of sodium phosphate buffer solution to make a 10%–20% lipid suspension. The resulting suspension was brought to the final mean vesicles size, of approximately 150 nm, by sequential filtration. The physicochemical characterization was based on: the evaluation of mean particle size and polydispersity index (PI) measured by photon correlation spectroscopy (PCS) and atomic force microscopy (AFM) topographic imaging; zeta potential (ζ-potential) and the SPC concentration determined by Laser–Doppler anemometry and an enzymatic-colorimetric test, respectively. The quantification of the incorporated Tretinoin and its chemical stability (during preparation and storage) was assayed by a HPLC at 342 nm.Results: It was possible to obtain the system Tretinoin-CyD-UDV. The mean vesicle size was the most stable parameter during experiments time course. AFM showed that Tretinoin-CyD-UDV samples were very heterogeneous in size, having three distinct subpopulations, while Tretinoin-UDV samples had only one homogeneous size population. The results of the ζ-potential measurements have shown that vesicle surface charge was low, as expected, presenting negative values. The incorporation efficiency was high, and no significant differences between Tretinoin-CyD-UDV and Tretinoin-UDV were observed. However, only Tretinoin-UDV with 20% lipid concentration formulation remained chemically stable during the evaluation period.Conclusion: According to our results, Tretinoin-UDV with 20% lipid concentration seems to be a better approach than Tretinoin-CyD-UDV, attending to the higher chemical stability." @default.
• W2003069632 created "2016-06-24" @default.
• W2003069632 creator A5000937137 @default.
• W2003069632 creator A5005184135 @default.
• W2003069632 creator A5018302151 @default.
• W2003069632 creator A5039891126 @default.
• W2003069632 creator A5041385495 @default.
• W2003069632 creator A5051074551 @default.
• W2003069632 creator A5060192358 @default.
• W2003069632 date "2013-04-30" @default.
• W2003069632 modified "2023-10-17" @default.
• W2003069632 title "Novel tretinoin formulations: a drug-in-cyclodextrin-in-liposome approach" @default.
• W2003069632 cites W142151810 @default.
• W2003069632 cites W1526743142 @default.
• W2003069632 cites W1965444922 @default.
• W2003069632 cites W1975937594 @default.
• W2003069632 cites W1981398993 @default.
• W2003069632 cites W1985111662 @default.
• W2003069632 cites W1987078254 @default.
• W2003069632 cites W1988635349 @default.
• W2003069632 cites W1990107938 @default.
• W2003069632 cites W1991376082 @default.
• W2003069632 cites W1992432352 @default.
• W2003069632 cites W2001353592 @default.
• W2003069632 cites W2002418262 @default.
• W2003069632 cites W2002843441 @default.
• W2003069632 cites W2006560775 @default.
• W2003069632 cites W2017134595 @default.
• W2003069632 cites W2024007314 @default.
• W2003069632 cites W2036582676 @default.
• W2003069632 cites W2037176643 @default.
• W2003069632 cites W2042177184 @default.
• W2003069632 cites W2046730110 @default.
• W2003069632 cites W2047817628 @default.
• W2003069632 cites W2051292995 @default.
• W2003069632 cites W2054872615 @default.
• W2003069632 cites W2056045451 @default.
• W2003069632 cites W2063250875 @default.
• W2003069632 cites W2065828981 @default.
• W2003069632 cites W2080014602 @default.
• W2003069632 cites W2080592247 @default.
• W2003069632 cites W2081534467 @default.
• W2003069632 cites W2086889742 @default.
• W2003069632 cites W2090379727 @default.
• W2003069632 cites W2090674283 @default.
• W2003069632 cites W2093374181 @default.
• W2003069632 cites W2094852979 @default.
• W2003069632 cites W2103846305 @default.
• W2003069632 cites W2113115289 @default.
• W2003069632 cites W2121539532 @default.
• W2003069632 cites W2122082335 @default.
• W2003069632 cites W2161034880 @default.
• W2003069632 doi "https://doi.org/10.3109/08982104.2013.788026" @default.
• W2003069632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23631723" @default.
• W2003069632 hasPublicationYear "2013" @default.
• W2003069632 type Work @default.
• W2003069632 sameAs 2003069632 @default.
• W2003069632 citedByCount "32" @default.
• W2003069632 countsByYear W20030696322014 @default.
• W2003069632 countsByYear W20030696322015 @default.
• W2003069632 countsByYear W20030696322016 @default.
• W2003069632 countsByYear W20030696322017 @default.
• W2003069632 countsByYear W20030696322018 @default.
• W2003069632 countsByYear W20030696322019 @default.
• W2003069632 countsByYear W20030696322020 @default.
• W2003069632 countsByYear W20030696322022 @default.
• W2003069632 crossrefType "journal-article" @default.
• W2003069632 hasAuthorship W2003069632A5000937137 @default.
• W2003069632 hasAuthorship W2003069632A5005184135 @default.
• W2003069632 hasAuthorship W2003069632A5018302151 @default.
• W2003069632 hasAuthorship W2003069632A5039891126 @default.
• W2003069632 hasAuthorship W2003069632A5041385495 @default.
• W2003069632 hasAuthorship W2003069632A5051074551 @default.
• W2003069632 hasAuthorship W2003069632A5060192358 @default.
• W2003069632 hasConcept C104317684 @default.
• W2003069632 hasConcept C11432220 @default.
• W2003069632 hasConcept C147789679 @default.
• W2003069632 hasConcept C155672457 @default.
• W2003069632 hasConcept C171250308 @default.
• W2003069632 hasConcept C178790620 @default.
• W2003069632 hasConcept C185154212 @default.
• W2003069632 hasConcept C185592680 @default.
• W2003069632 hasConcept C187530423 @default.
• W2003069632 hasConcept C192562407 @default.
• W2003069632 hasConcept C2779963572 @default.
• W2003069632 hasConcept C2781121885 @default.
• W2003069632 hasConcept C43617362 @default.
• W2003069632 hasConcept C55493867 @default.
• W2003069632 hasConcept C86181022 @default.
• W2003069632 hasConceptScore W2003069632C104317684 @default.
• W2003069632 hasConceptScore W2003069632C11432220 @default.
• W2003069632 hasConceptScore W2003069632C147789679 @default.
• W2003069632 hasConceptScore W2003069632C155672457 @default.
• W2003069632 hasConceptScore W2003069632C171250308 @default.
• W2003069632 hasConceptScore W2003069632C178790620 @default.
• W2003069632 hasConceptScore W2003069632C185154212 @default.
• W2003069632 hasConceptScore W2003069632C185592680 @default.
• W2003069632 hasConceptScore W2003069632C187530423 @default.

• next