FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003078245> ?p ?o ?g. }

• W2003078245 endingPage "679" @default.
• W2003078245 startingPage "667" @default.
• W2003078245 abstract "Hyperhomocysteinemia has been identified as a risk factor for neurological disorders. To study the influence of early deficiency in nutritional determinants of hyperhomocysteinemia on the developing rat brain, dams were fed a standard diet or a diet lacking methyl groups during gestation and lactation. Homocysteinemia progressively increased in the offspring of the deficient group and at 21 days reached 13.3+/-3.7 micromol/L versus 6.8+/-0.3 micromol/L in controls. Homocysteine accumulated in both neurons and astrocytes of selective brain structures including the hippocampus, the cerebellum, the striatum, and the neurogenic subventricular zone. Most homocysteine-positive cells expressed p53 and displayed fragmented DNA indicative of apoptosis. Righting reflex and negative geotaxis revealed a delay in the onset of integration capacities in the deficient group. Between 19 and 21 days, a poorer success score was recorded in deficient animals in a locomotor coordination test. A switch to normal food after weaning allowed restoration of normal homocysteinemia. Nevertheless, at 80 days of age, the exploratory behavior in the elevated-plus maze and the learning and memory behavior in the eight-arm maze revealed that early vitamin B deprivation is associated with persistent functional disabilities, possibly resulting from the ensuing neurotoxic effects of homocysteine." @default.
• W2003078245 created "2016-06-24" @default.
• W2003078245 creator A5001331543 @default.
• W2003078245 creator A5019095895 @default.
• W2003078245 creator A5022473309 @default.
• W2003078245 creator A5024743509 @default.
• W2003078245 creator A5025764803 @default.
• W2003078245 creator A5033155748 @default.
• W2003078245 creator A5078573429 @default.
• W2003078245 date "2007-02-01" @default.
• W2003078245 modified "2023-10-18" @default.
• W2003078245 title "Gestational Vitamin B Deficiency Leads to Homocysteine-Associated Brain Apoptosis and Alters Neurobehavioral Development in Rats" @default.
• W2003078245 cites W1502696355 @default.
• W2003078245 cites W1584910935 @default.
• W2003078245 cites W1622554361 @default.
• W2003078245 cites W1931355593 @default.
• W2003078245 cites W1968620765 @default.
• W2003078245 cites W1970525290 @default.
• W2003078245 cites W1970975032 @default.
• W2003078245 cites W1974630582 @default.
• W2003078245 cites W1977841860 @default.
• W2003078245 cites W1980954348 @default.
• W2003078245 cites W1982341626 @default.
• W2003078245 cites W1985657039 @default.
• W2003078245 cites W1991022221 @default.
• W2003078245 cites W1995152432 @default.
• W2003078245 cites W1997546112 @default.
• W2003078245 cites W2001744417 @default.
• W2003078245 cites W2003084130 @default.
• W2003078245 cites W2003432290 @default.
• W2003078245 cites W2004026462 @default.
• W2003078245 cites W2017838536 @default.
• W2003078245 cites W2021235898 @default.
• W2003078245 cites W2031923013 @default.
• W2003078245 cites W2035655203 @default.
• W2003078245 cites W2036089634 @default.
• W2003078245 cites W2037277347 @default.
• W2003078245 cites W2041561931 @default.
• W2003078245 cites W2050365720 @default.
• W2003078245 cites W2050875261 @default.
• W2003078245 cites W2051904995 @default.
• W2003078245 cites W2052211882 @default.
• W2003078245 cites W2052422381 @default.
• W2003078245 cites W2052588755 @default.
• W2003078245 cites W2054119137 @default.
• W2003078245 cites W2067535022 @default.
• W2003078245 cites W2074602389 @default.
• W2003078245 cites W2079714323 @default.
• W2003078245 cites W2085527691 @default.
• W2003078245 cites W2089657261 @default.
• W2003078245 cites W2094311708 @default.
• W2003078245 cites W2095133395 @default.
• W2003078245 cites W2097478746 @default.
• W2003078245 cites W2104575676 @default.
• W2003078245 cites W2108484297 @default.
• W2003078245 cites W2110588833 @default.
• W2003078245 cites W2114829862 @default.
• W2003078245 cites W2115446921 @default.
• W2003078245 cites W2115609680 @default.
• W2003078245 cites W2121277395 @default.
• W2003078245 cites W2126230337 @default.
• W2003078245 cites W2128635872 @default.
• W2003078245 cites W2134479104 @default.
• W2003078245 cites W2155638653 @default.
• W2003078245 cites W2157862480 @default.
• W2003078245 cites W2164911583 @default.
• W2003078245 cites W2166248226 @default.
• W2003078245 cites W2166439489 @default.
• W2003078245 cites W2894952440 @default.
• W2003078245 cites W4293247451 @default.
• W2003078245 doi "https://doi.org/10.2353/ajpath.2007.060339" @default.
• W2003078245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1851855" @default.
• W2003078245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17255334" @default.
• W2003078245 hasPublicationYear "2007" @default.
• W2003078245 type Work @default.
• W2003078245 sameAs 2003078245 @default.
• W2003078245 citedByCount "138" @default.
• W2003078245 countsByYear W20030782452012 @default.
• W2003078245 countsByYear W20030782452013 @default.
• W2003078245 countsByYear W20030782452014 @default.
• W2003078245 countsByYear W20030782452015 @default.
• W2003078245 countsByYear W20030782452016 @default.
• W2003078245 countsByYear W20030782452017 @default.
• W2003078245 countsByYear W20030782452018 @default.
• W2003078245 countsByYear W20030782452019 @default.
• W2003078245 countsByYear W20030782452020 @default.
• W2003078245 countsByYear W20030782452021 @default.
• W2003078245 countsByYear W20030782452022 @default.
• W2003078245 countsByYear W20030782452023 @default.
• W2003078245 crossrefType "journal-article" @default.
• W2003078245 hasAuthorship W2003078245A5001331543 @default.
• W2003078245 hasAuthorship W2003078245A5019095895 @default.
• W2003078245 hasAuthorship W2003078245A5022473309 @default.
• W2003078245 hasAuthorship W2003078245A5024743509 @default.
• W2003078245 hasAuthorship W2003078245A5025764803 @default.
• W2003078245 hasAuthorship W2003078245A5033155748 @default.
• W2003078245 hasAuthorship W2003078245A5078573429 @default.
• W2003078245 hasBestOaLocation W20030782451 @default.

• next