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• W2003078384 abstract "In order to examine that the effects of interferon alpha (IFN-α) on the production of reactive oxygen species from human neutrophils, we investigated in vitro effects of IFN-α on neutrophil chemiluminescence responses. Human neutrophils were incubated with 0–1 × 105 IU/mL IFN-α for 10–60 min just before stimulation with opsonized zymosan and phorbol 12-myristate 13-acetate. Luminol-dependent (LmCL) and lucigenin-dependent (LgCL) chemiluminescence responses were measured using a Lumi Box H-1000. The LmCL response was inhibited by pre-incubation with high concentrations of IFN-α (more than 1 × 104 IU/mL). In contrast, LgCL response was increased when neutrophils were pre-incubated with high concentration of IFN-α. Effects of pre-incubation of IFN-α were similar between CL responses stimulated with OZ and PMA. The increase of LgCL might be due to the inhibitory effect of IFN-α on myeloperoxidase degranulation, in view of the decreased LmCL responses. Copyright © 2001 John Wiley & Sons, Ltd." @default.
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• W2003078384 date "2001-01-01" @default.
• W2003078384 modified "2023-09-27" @default.
• W2003078384 title "Effect of interferon-? on production of reactive oxygen species by human neutrophils" @default.
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• W2003078384 doi "https://doi.org/10.1002/bio.606" @default.
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