FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003079314> ?p ?o ?g. }

• W2003079314 endingPage "1066" @default.
• W2003079314 startingPage "1061" @default.
• W2003079314 abstract "Spatial working memory or short-term place memory is impaired in schizophrenia. The efficiency of antipsychotic drugs, particularly of typical antipsychotics, on cognitive deficit in schizophrenia remains disputable. Inhibition of serotonin (5-HT) 2A/2C receptors is important for cognitive improvement in schizophrenic patients treated with antipsychotics. The aim of the present work was to establish the effect of the 5-HT2A/2C receptor antagonist ritanserin (2.5 or 5 mg/kg), the dopamine D2 antagonist haloperidol (0.1 or 1 mg/kg), and the atypical antipsychotic risperidone (0.1 mg/kg or 1 mg/kg), which is an antagonist of both 5-HT2A/2C and D2 receptors, on cognitive deficit induced by subchronic administration of dizocilpine (MK-801, 0.1 mg/kg). We used the active allothetic place avoidance (AAPA) task, requiring the rat to differentiate between relevant and irrelevant stimuli, in a way similar to disruption of information processing disturbed in schizophrenic patients. Our results show that treatment with 5-HT2A/2C receptor antagonists, regardless of their effect on D2 receptors, blocked the cognitive impairment produced by MK-801. Haloperidol did not sufficiently reduce the deficit in AAPA induced by MK-801. Interestingly, administration of risperidone and haloperidol alone, but not ritanserin, impaired the AAPA performance in intact rats. Ritanserin and risperidone actually improve cognition independently of their effect on locomotor activity in an animal model of schizophrenia-like behavior. This finding is in accordance with the assumption that some antipsychotics are primarily effective against cognitive dysfunction in schizophrenia." @default.
• W2003079314 created "2016-06-24" @default.
• W2003079314 creator A5012749149 @default.
• W2003079314 creator A5015226184 @default.
• W2003079314 creator A5035661754 @default.
• W2003079314 creator A5039379035 @default.
• W2003079314 creator A5070653866 @default.
• W2003079314 date "2008-01-22" @default.
• W2003079314 modified "2023-10-18" @default.
• W2003079314 title "Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task" @default.
• W2003079314 cites W1970056072 @default.
• W2003079314 cites W1975682905 @default.
• W2003079314 cites W1978748886 @default.
• W2003079314 cites W1985674713 @default.
• W2003079314 cites W1990661023 @default.
• W2003079314 cites W1990673661 @default.
• W2003079314 cites W1997129578 @default.
• W2003079314 cites W1997399269 @default.
• W2003079314 cites W2000375438 @default.
• W2003079314 cites W2004288203 @default.
• W2003079314 cites W2005756201 @default.
• W2003079314 cites W2027015583 @default.
• W2003079314 cites W2036273649 @default.
• W2003079314 cites W2038183246 @default.
• W2003079314 cites W2039182248 @default.
• W2003079314 cites W2039553065 @default.
• W2003079314 cites W2051011222 @default.
• W2003079314 cites W2058889376 @default.
• W2003079314 cites W2069109778 @default.
• W2003079314 cites W2076877247 @default.
• W2003079314 cites W2078879288 @default.
• W2003079314 cites W2083346490 @default.
• W2003079314 cites W2084926458 @default.
• W2003079314 cites W2085712731 @default.
• W2003079314 cites W2095213614 @default.
• W2003079314 cites W2099635835 @default.
• W2003079314 cites W2106352416 @default.
• W2003079314 cites W2107406913 @default.
• W2003079314 cites W2112764261 @default.
• W2003079314 cites W2134729998 @default.
• W2003079314 cites W2138368199 @default.
• W2003079314 cites W2140156016 @default.
• W2003079314 cites W2140249810 @default.
• W2003079314 cites W2145453003 @default.
• W2003079314 cites W2158137297 @default.
• W2003079314 cites W2224161568 @default.
• W2003079314 cites W2345907171 @default.
• W2003079314 cites W2924293519 @default.
• W2003079314 cites W4245655064 @default.
• W2003079314 cites W73844516 @default.
• W2003079314 doi "https://doi.org/10.1073/pnas.0711273105" @default.
• W2003079314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2242716" @default.
• W2003079314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18195350" @default.
• W2003079314 hasPublicationYear "2008" @default.
• W2003079314 type Work @default.
• W2003079314 sameAs 2003079314 @default.
• W2003079314 citedByCount "40" @default.
• W2003079314 countsByYear W20030793142012 @default.
• W2003079314 countsByYear W20030793142013 @default.
• W2003079314 countsByYear W20030793142014 @default.
• W2003079314 countsByYear W20030793142015 @default.
• W2003079314 countsByYear W20030793142016 @default.
• W2003079314 countsByYear W20030793142017 @default.
• W2003079314 countsByYear W20030793142018 @default.
• W2003079314 countsByYear W20030793142020 @default.
• W2003079314 countsByYear W20030793142021 @default.
• W2003079314 countsByYear W20030793142022 @default.
• W2003079314 crossrefType "journal-article" @default.
• W2003079314 hasAuthorship W2003079314A5012749149 @default.
• W2003079314 hasAuthorship W2003079314A5015226184 @default.
• W2003079314 hasAuthorship W2003079314A5035661754 @default.
• W2003079314 hasAuthorship W2003079314A5039379035 @default.
• W2003079314 hasAuthorship W2003079314A5070653866 @default.
• W2003079314 hasBestOaLocation W20030793141 @default.
• W2003079314 hasConcept C118552586 @default.
• W2003079314 hasConcept C126322002 @default.
• W2003079314 hasConcept C15744967 @default.
• W2003079314 hasConcept C169760540 @default.
• W2003079314 hasConcept C169900460 @default.
• W2003079314 hasConcept C170493617 @default.
• W2003079314 hasConcept C2775870346 @default.
• W2003079314 hasConcept C2776412080 @default.
• W2003079314 hasConcept C2776885963 @default.
• W2003079314 hasConcept C2776921671 @default.
• W2003079314 hasConcept C2777450907 @default.
• W2003079314 hasConcept C2777836312 @default.
• W2003079314 hasConcept C2778122271 @default.
• W2003079314 hasConcept C2779727114 @default.
• W2003079314 hasConcept C2780057945 @default.
• W2003079314 hasConcept C2780494398 @default.
• W2003079314 hasConcept C2780749935 @default.
• W2003079314 hasConcept C2780948584 @default.
• W2003079314 hasConcept C2984915365 @default.
• W2003079314 hasConcept C44208683 @default.
• W2003079314 hasConcept C513476851 @default.
• W2003079314 hasConcept C67018056 @default.
• W2003079314 hasConcept C71924100 @default.
• W2003079314 hasConcept C98274493 @default.

• next