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- W2003079594 abstract "1351 Measuring the dynamics of blood flow and metabolic changes in skeletal muscle during exercise is important for understanding aspects of muscle physiology. The acquisition of both spatially and temporally localized perfusion measurements within working muscle is desirable, but is difficult to obtain. Standard methods that can achieve temporal resolution, such as blood-gas extraction, thermodilution, or plethysmography, allow measurements from entire muscle groups but cannot resolve activity within muscle groups. Methods using microspheres, on the other hand, are able to determine the spatial distribution of flow at one time point but are more difficult to use for the study of dynamics because of the need to use distinguishable microspheres for each time point. We have used magnetic resonance images acquired using an arterial spin labeling technique to show spatial and temporal variations of perfusion in the skeletal muscle of exercising humans. This technique involves magnetically tagging blood proximal to an imaging slice, then observing the changes that occur as the blood flows into that slice. Measurements are made directly from rapidly acquired MR images, and so provide both spatial and temporal information. Because no contrast agent is used, they are completely non-invasive. Measured perfusion values were consistent with those obtained with traditional techniques reported in the literature. This method can provide a useful tool in the study of muscle physiology." @default.
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- W2003079594 date "1999-05-01" @default.
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- W2003079594 title "QUANTITATIVE DYNAMIC IMAGING OF PERFUSION IN HUMAN SKELETAL MUSCLE DURING EXERCISE WITH ARTERIAL SPIN LABELIN" @default.
- W2003079594 doi "https://doi.org/10.1097/00005768-199905001-01347" @default.
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