Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003080384> ?p ?o ?g. }
- W2003080384 endingPage "141" @default.
- W2003080384 startingPage "131" @default.
- W2003080384 abstract "Systematic investigations on the diffusion of ibuprofen (IBU) from supersaturated solutions through human epidermis are reported. Significant flux enhancement was obtained from supersaturated solutions compared to the saturated solution. Hydroxypropyl methylcellulose (HPMC), when used as an additive was found to be effective in maintaining the high activity state at high degrees of saturation (DS). The increase in the flux was proportional to the DS. In the presence of 2-hydroxypropyl-β-cyclodextrin (CD) at DS 2 and 3 a lower flux was observed compared to HPMC. At DS 5 a higher flux enhancement was found suggesting that CD might act as a penetration enhancer at certain CD/drug ratios. Studies on the mechanism of stabilisation of HPMC and CD on IBU crystallisation from supersaturated systems showed that HPMC acts as a growth inhibitor and habit modifier whereas CD does not influence the crystallisation process." @default.
- W2003080384 created "2016-06-24" @default.
- W2003080384 creator A5002016245 @default.
- W2003080384 creator A5029198962 @default.
- W2003080384 creator A5059741959 @default.
- W2003080384 creator A5075454754 @default.
- W2003080384 date "2001-01-05" @default.
- W2003080384 modified "2023-10-10" @default.
- W2003080384 title "Penetration enhancement of ibuprofen from supersaturated solutions through human skin" @default.
- W2003080384 cites W1543696264 @default.
- W2003080384 cites W1964513393 @default.
- W2003080384 cites W1989700427 @default.
- W2003080384 cites W2021713550 @default.
- W2003080384 cites W2023439288 @default.
- W2003080384 cites W2023886434 @default.
- W2003080384 cites W2024897759 @default.
- W2003080384 cites W2029573539 @default.
- W2003080384 cites W2037734347 @default.
- W2003080384 cites W2040878490 @default.
- W2003080384 cites W2048334983 @default.
- W2003080384 cites W2054757178 @default.
- W2003080384 cites W2055126493 @default.
- W2003080384 cites W2057860966 @default.
- W2003080384 cites W2059829176 @default.
- W2003080384 cites W2062966281 @default.
- W2003080384 cites W2066569939 @default.
- W2003080384 cites W2067858340 @default.
- W2003080384 cites W2079574505 @default.
- W2003080384 cites W2079882248 @default.
- W2003080384 cites W2083676975 @default.
- W2003080384 cites W2088776819 @default.
- W2003080384 cites W2141331305 @default.
- W2003080384 cites W2283449839 @default.
- W2003080384 cites W34308943 @default.
- W2003080384 cites W2472162670 @default.
- W2003080384 doi "https://doi.org/10.1016/s0378-5173(00)00603-7" @default.
- W2003080384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11165828" @default.
- W2003080384 hasPublicationYear "2001" @default.
- W2003080384 type Work @default.
- W2003080384 sameAs 2003080384 @default.
- W2003080384 citedByCount "111" @default.
- W2003080384 countsByYear W20030803842012 @default.
- W2003080384 countsByYear W20030803842013 @default.
- W2003080384 countsByYear W20030803842014 @default.
- W2003080384 countsByYear W20030803842015 @default.
- W2003080384 countsByYear W20030803842016 @default.
- W2003080384 countsByYear W20030803842017 @default.
- W2003080384 countsByYear W20030803842018 @default.
- W2003080384 countsByYear W20030803842019 @default.
- W2003080384 countsByYear W20030803842020 @default.
- W2003080384 countsByYear W20030803842021 @default.
- W2003080384 countsByYear W20030803842022 @default.
- W2003080384 countsByYear W20030803842023 @default.
- W2003080384 crossrefType "journal-article" @default.
- W2003080384 hasAuthorship W2003080384A5002016245 @default.
- W2003080384 hasAuthorship W2003080384A5029198962 @default.
- W2003080384 hasAuthorship W2003080384A5059741959 @default.
- W2003080384 hasAuthorship W2003080384A5075454754 @default.
- W2003080384 hasConcept C114614502 @default.
- W2003080384 hasConcept C12554922 @default.
- W2003080384 hasConcept C127413603 @default.
- W2003080384 hasConcept C155574463 @default.
- W2003080384 hasConcept C178790620 @default.
- W2003080384 hasConcept C185592680 @default.
- W2003080384 hasConcept C192562407 @default.
- W2003080384 hasConcept C200447597 @default.
- W2003080384 hasConcept C203036418 @default.
- W2003080384 hasConcept C2779944601 @default.
- W2003080384 hasConcept C33923547 @default.
- W2003080384 hasConcept C42360764 @default.
- W2003080384 hasConcept C42475967 @default.
- W2003080384 hasConcept C43617362 @default.
- W2003080384 hasConcept C71924100 @default.
- W2003080384 hasConcept C80107235 @default.
- W2003080384 hasConcept C86803240 @default.
- W2003080384 hasConcept C98274493 @default.
- W2003080384 hasConcept C9930424 @default.
- W2003080384 hasConceptScore W2003080384C114614502 @default.
- W2003080384 hasConceptScore W2003080384C12554922 @default.
- W2003080384 hasConceptScore W2003080384C127413603 @default.
- W2003080384 hasConceptScore W2003080384C155574463 @default.
- W2003080384 hasConceptScore W2003080384C178790620 @default.
- W2003080384 hasConceptScore W2003080384C185592680 @default.
- W2003080384 hasConceptScore W2003080384C192562407 @default.
- W2003080384 hasConceptScore W2003080384C200447597 @default.
- W2003080384 hasConceptScore W2003080384C203036418 @default.
- W2003080384 hasConceptScore W2003080384C2779944601 @default.
- W2003080384 hasConceptScore W2003080384C33923547 @default.
- W2003080384 hasConceptScore W2003080384C42360764 @default.
- W2003080384 hasConceptScore W2003080384C42475967 @default.
- W2003080384 hasConceptScore W2003080384C43617362 @default.
- W2003080384 hasConceptScore W2003080384C71924100 @default.
- W2003080384 hasConceptScore W2003080384C80107235 @default.
- W2003080384 hasConceptScore W2003080384C86803240 @default.
- W2003080384 hasConceptScore W2003080384C98274493 @default.
- W2003080384 hasConceptScore W2003080384C9930424 @default.
- W2003080384 hasIssue "1" @default.
- W2003080384 hasLocation W20030803841 @default.