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- W2003088052 abstract "Proteinuria was found in Fischer female rats after a single ip injection of NiCl2 in dosages from 34 to 85 μmol/kg (2–5 mg Ni/kg). Generalized α-aminoaciduria was found after a single ip injection of NiCl2 in dosages of 68 and 85 μmol/kg (4 and 5 mg Ni/kg). Amino acids in plasma were normal or slightly diminished from 1 to 48 hr after injection of Ni(II). Electron microscopy of kidneys of five rats at 48 hr after Ni(II) (68 μmol/kg) consistently revealed fusion of foot processes of glomerular epithelial cells. Focal tubular necrosis was present in the kidney of one of these rats. This study demonstrates that toxic nephrophathy with aminoaciduria and proteinuria develops in rats after ip Ni(II). Amino acid and protein excretions consistently returned to normal by Day 5." @default.
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- W2003088052 date "1975-12-01" @default.
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- W2003088052 title "Aminoaciduria and proteinuria in rats after a single intraperitoneal injection of Ni(II)" @default.
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- W2003088052 doi "https://doi.org/10.1016/0041-008x(75)90136-2" @default.
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