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- W2003089715 abstract "The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a role in cognitive and homeostatic functions. Drug discovery efforts by numerous pharmaceutical companies have focused on the preclinical development of H3 receptor antagonists for the potential treatment of attention-deficit hyperactivity disorder, dementias, schizophrenia, as well as obesity and sleep disorders. This receptor exhibits molecular, pharmacological, and functional heterogeneity that informs the preclinical development of effective antagonists. Herein, we describe the biological and chemical implications for developing H3 receptor antagonists and their therapeutic potential as disclosed through animal models of cognition, sleep, and obesity." @default.
- W2003089715 created "2016-06-24" @default.
- W2003089715 creator A5077775325 @default.
- W2003089715 date "2006-04-01" @default.
- W2003089715 modified "2023-09-25" @default.
- W2003089715 title "Histamine H3 Receptor Antagonists: Preclinical Promise for Treating Obesity and Cognitive Disorders" @default.
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- W2003089715 doi "https://doi.org/10.1124/mi.6.2.5" @default.
- W2003089715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16565470" @default.
- W2003089715 hasPublicationYear "2006" @default.
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