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- W2003092258 abstract "The socio-sexual and exploratory behaviour profiles were studied in male rats after intracerebral administration of beta-endorphin and morphine. Two social test situations were used, one with a sexually receptive female and one with a castrated male as the stimulus subject. Time (10-60 min)-response and dose (0.25-5.0 millimicron)-response relationships were investigated. A dose of 5 millimicron of beta-endorphin or morphine decreased exploratory activity and socio-sexual approaches. At lower doses (0.5-1.0 millimicron) beta-endorphin produced a more selective inhibitory effect on copulatory behaviour than morphine, which still caused a general depression of both social and sexual behaviours. In contrast to morphine, beta-endorphin increased amicable social contacts at a dose (1 millimicron) which decrease sexual responses. The dissimilarities in morphine and beta-endorphin effects suggest involvement of different brain areas or opiate receptors. The particular behaviour profiles observed after treatment with beta-endorphin indicate the possibility that beta-endorphin influences mechanisms implicated in perception or interpretation of environmental stimuli." @default.
- W2003092258 created "2016-06-24" @default.
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- W2003092258 date "1981-02-01" @default.
- W2003092258 modified "2023-09-25" @default.
- W2003092258 title "Comparison of the effects of β-endorphin and morphine on exploratory and socio-sexual behaviour in the male rat" @default.
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- W2003092258 doi "https://doi.org/10.1016/0014-2999(81)90449-0" @default.
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