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- W2003096054 abstract "Positive selection of T cells begins with TCRαβlo thymic progenitors. Here, we show that the most efficient TCRlo progenitors are c-kit+ with intermediate levels of CD4 and CD8 (DPint). Positive selection of DPint TCRlo c-kit+ cells results in TCRmed CD69+ c-kit+ transitional intermediates that show increased TCRVβ frequencies to selecting superantigen (SAg) that are committed to the CD4 or CD8 pathway. The cells on the c-kit+ maturation pathway maintain Bcl-2 expression. Most DPint c-kit+ progenitors fail positive selection, and become DPhi c-kit− cells that lose Bcl-2 expression. Some DPhi c-kit− blast cells can be salvaged to produce mature single-positive (SP) cells. DPint c-kit+ maturation to SP cells can occur in <12 hr in vitro on thymic stromal monolayers." @default.
- W2003096054 created "2016-06-24" @default.
- W2003096054 creator A5026278665 @default.
- W2003096054 creator A5082894731 @default.
- W2003096054 date "1996-08-01" @default.
- W2003096054 modified "2023-10-18" @default.
- W2003096054 title "The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection" @default.
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- W2003096054 doi "https://doi.org/10.1016/s1074-7613(00)80491-4" @default.
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