Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003100608> ?p ?o ?g. }
- W2003100608 endingPage "851" @default.
- W2003100608 startingPage "846" @default.
- W2003100608 abstract "Major depressive disorder (MDD) has been associated with dysregulated immune systems and impaired T cell function, but data on depression-related alterations in the levels of immunomodulatory growth factors are scarce. In order to further clarify the mechanisms underlying immune system dysregulation in depressed subjects, we examined the associations between MDD and serum levels of two immunomodulatory growth factors, interleukin (IL)-7 and granulocyte-colony stimulating factor (G-CSF), in 122 subjects (MDD with long-term symptomatology, n=61; controls, n=61). The MDD subjects had lowered levels of IL-7. In a model adjusted for age, gender and body mass index, subjects in the lowest tertile of IL-7 had a 3.4-fold increased likelihood for MDD (p=0.010). Further adjustments for sleep disturbances, alcohol use, smoking, and metabolic syndrome did not alter these findings. Moreover, the exclusion of subjects with rheumatoid arthritis, coronary heart disease, or the use of non-steroidal anti-inflammatory medications or oral corticosteroids only slightly attenuated the findings. The G-CSF levels did not differ between the two groups. The lowering of the serum levels of IL-7, a regulator of T cell homeostasis, in MDD subjects may underlie the depression-related impaired T cell function." @default.
- W2003100608 created "2016-06-24" @default.
- W2003100608 creator A5009394024 @default.
- W2003100608 creator A5017412825 @default.
- W2003100608 creator A5024145797 @default.
- W2003100608 creator A5028169262 @default.
- W2003100608 creator A5030462166 @default.
- W2003100608 creator A5048168425 @default.
- W2003100608 creator A5060662253 @default.
- W2003100608 creator A5064792374 @default.
- W2003100608 creator A5070512279 @default.
- W2003100608 creator A5083045296 @default.
- W2003100608 creator A5084326560 @default.
- W2003100608 date "2010-08-01" @default.
- W2003100608 modified "2023-09-27" @default.
- W2003100608 title "Serum IL-7 and G-CSF in major depressive disorder" @default.
- W2003100608 cites W1522375197 @default.
- W2003100608 cites W176230280 @default.
- W2003100608 cites W1964368905 @default.
- W2003100608 cites W1971295949 @default.
- W2003100608 cites W1977812814 @default.
- W2003100608 cites W1985438873 @default.
- W2003100608 cites W1986031269 @default.
- W2003100608 cites W1990808205 @default.
- W2003100608 cites W1991862424 @default.
- W2003100608 cites W1993763786 @default.
- W2003100608 cites W1996454121 @default.
- W2003100608 cites W2001010891 @default.
- W2003100608 cites W2007116949 @default.
- W2003100608 cites W2007928557 @default.
- W2003100608 cites W2008005358 @default.
- W2003100608 cites W2022634896 @default.
- W2003100608 cites W2024448645 @default.
- W2003100608 cites W2024726128 @default.
- W2003100608 cites W2033179357 @default.
- W2003100608 cites W2037084854 @default.
- W2003100608 cites W2038333667 @default.
- W2003100608 cites W2046357922 @default.
- W2003100608 cites W2049865797 @default.
- W2003100608 cites W2050705882 @default.
- W2003100608 cites W2052445727 @default.
- W2003100608 cites W2055795081 @default.
- W2003100608 cites W2063965093 @default.
- W2003100608 cites W2067495470 @default.
- W2003100608 cites W2067596888 @default.
- W2003100608 cites W2069493420 @default.
- W2003100608 cites W2082797461 @default.
- W2003100608 cites W2088751222 @default.
- W2003100608 cites W2089417699 @default.
- W2003100608 cites W2090515685 @default.
- W2003100608 cites W2097740790 @default.
- W2003100608 cites W2103097055 @default.
- W2003100608 cites W2103714496 @default.
- W2003100608 cites W2114391923 @default.
- W2003100608 cites W2115349822 @default.
- W2003100608 cites W2118941602 @default.
- W2003100608 cites W2121780454 @default.
- W2003100608 cites W2133789177 @default.
- W2003100608 cites W2142631525 @default.
- W2003100608 cites W2149069297 @default.
- W2003100608 cites W2164978865 @default.
- W2003100608 cites W2165786903 @default.
- W2003100608 cites W2170857085 @default.
- W2003100608 cites W4238251256 @default.
- W2003100608 doi "https://doi.org/10.1016/j.pnpbp.2010.03.033" @default.
- W2003100608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20382196" @default.
- W2003100608 hasPublicationYear "2010" @default.
- W2003100608 type Work @default.
- W2003100608 sameAs 2003100608 @default.
- W2003100608 citedByCount "29" @default.
- W2003100608 countsByYear W20031006082012 @default.
- W2003100608 countsByYear W20031006082013 @default.
- W2003100608 countsByYear W20031006082015 @default.
- W2003100608 countsByYear W20031006082016 @default.
- W2003100608 countsByYear W20031006082017 @default.
- W2003100608 countsByYear W20031006082019 @default.
- W2003100608 countsByYear W20031006082020 @default.
- W2003100608 countsByYear W20031006082021 @default.
- W2003100608 countsByYear W20031006082022 @default.
- W2003100608 countsByYear W20031006082023 @default.
- W2003100608 crossrefType "journal-article" @default.
- W2003100608 hasAuthorship W2003100608A5009394024 @default.
- W2003100608 hasAuthorship W2003100608A5017412825 @default.
- W2003100608 hasAuthorship W2003100608A5024145797 @default.
- W2003100608 hasAuthorship W2003100608A5028169262 @default.
- W2003100608 hasAuthorship W2003100608A5030462166 @default.
- W2003100608 hasAuthorship W2003100608A5048168425 @default.
- W2003100608 hasAuthorship W2003100608A5060662253 @default.
- W2003100608 hasAuthorship W2003100608A5064792374 @default.
- W2003100608 hasAuthorship W2003100608A5070512279 @default.
- W2003100608 hasAuthorship W2003100608A5083045296 @default.
- W2003100608 hasAuthorship W2003100608A5084326560 @default.
- W2003100608 hasConcept C126322002 @default.
- W2003100608 hasConcept C134018914 @default.
- W2003100608 hasConcept C139719470 @default.
- W2003100608 hasConcept C15744967 @default.
- W2003100608 hasConcept C162324750 @default.
- W2003100608 hasConcept C203014093 @default.