FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003103967> ?p ?o ?g. }

• W2003103967 endingPage "103" @default.
• W2003103967 startingPage "92" @default.
• W2003103967 abstract "Background: Atazanavir boosted with ritonavir (ATV/r) and efavirenz (EFV) are both recommended as first-line therapies for HIV-infected patients. We compared the 2 therapies for virologic efficacy and immune recovery. Methods: We included all treatment-naïve patients in the Swiss HIV Cohort Study starting therapy after May 2003 with either ATV/r or EFV and a backbone of tenofovir and either emtricitabine or lamivudine. We used Cox models to assess time to virologic failure and repeated measures models to assess the change in CD4 cell counts over time. All models were fit as marginal structural models using both point of treatment and censoring weights. Intent-to-treat and various as-treated analyses were carried out: In the latter, patients were censored at their last recorded measurement if they changed therapy or if they were no longer adherent to therapy. Results: Patients starting EFV (n = 1,097) and ATV/r (n = 384) were followed for a median of 35 and 37 months, respectively. During follow-up, 51% patients on EFV and 33% patients on ATV/r remained adherent and made no change to their first-line therapy. Although intent-to-treat analyses suggest virologic failure was more likely with ATV/r, there was no evidence for this disadvantage in patients who adhered to first-line therapy. Patients starting ATV/r had a greater increase in CD4 cell count during the first year of therapy, but this advantage disappeared after one year. Conclusions: In this observational study, there was no good evidence of any intrinsic advantage for one therapy over the other, consistent with earlier clinical trials. Differences between therapies may arise in a clinical setting because of differences in adherence to therapy." @default.
• W2003103967 created "2016-06-24" @default.
• W2003103967 creator A5003503698 @default.
• W2003103967 creator A5011217027 @default.
• W2003103967 creator A5018546528 @default.
• W2003103967 creator A5032299448 @default.
• W2003103967 creator A5059371192 @default.
• W2003103967 creator A5070278395 @default.
• W2003103967 creator A5070365161 @default.
• W2003103967 creator A5072315367 @default.
• W2003103967 creator A5077441882 @default.
• W2003103967 creator A5080523158 @default.
• W2003103967 date "2014-06-01" @default.
• W2003103967 modified "2023-10-16" @default.
• W2003103967 title "Virologic and Immunologic Responses in Treatment-Naive Patients to Ritonavir-Boosted Atazanavir or Efavirenz With a Common Backbone" @default.
• W2003103967 cites W1488316909 @default.
• W2003103967 cites W1914178162 @default.
• W2003103967 cites W1982932793 @default.
• W2003103967 cites W2005404141 @default.
• W2003103967 cites W2005528359 @default.
• W2003103967 cites W2008557562 @default.
• W2003103967 cites W2016264635 @default.
• W2003103967 cites W2019690398 @default.
• W2003103967 cites W2029174775 @default.
• W2003103967 cites W2043884818 @default.
• W2003103967 cites W2054461097 @default.
• W2003103967 cites W2055678673 @default.
• W2003103967 cites W2067676871 @default.
• W2003103967 cites W2069091142 @default.
• W2003103967 cites W2078862756 @default.
• W2003103967 cites W2099354741 @default.
• W2003103967 cites W2117740478 @default.
• W2003103967 cites W2139276221 @default.
• W2003103967 cites W2141230205 @default.
• W2003103967 cites W2142495742 @default.
• W2003103967 cites W2146676275 @default.
• W2003103967 cites W2148750104 @default.
• W2003103967 cites W2150771174 @default.
• W2003103967 cites W2153670371 @default.
• W2003103967 cites W2155965977 @default.
• W2003103967 cites W2158934554 @default.
• W2003103967 cites W2167155110 @default.
• W2003103967 cites W2167877735 @default.
• W2003103967 cites W4248936568 @default.
• W2003103967 doi "https://doi.org/10.1310/hct1503-92" @default.
• W2003103967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24947533" @default.
• W2003103967 hasPublicationYear "2014" @default.
• W2003103967 type Work @default.
• W2003103967 sameAs 2003103967 @default.
• W2003103967 citedByCount "4" @default.
• W2003103967 countsByYear W20031039672015 @default.
• W2003103967 countsByYear W20031039672016 @default.
• W2003103967 countsByYear W20031039672019 @default.
• W2003103967 crossrefType "journal-article" @default.
• W2003103967 hasAuthorship W2003103967A5003503698 @default.
• W2003103967 hasAuthorship W2003103967A5011217027 @default.
• W2003103967 hasAuthorship W2003103967A5018546528 @default.
• W2003103967 hasAuthorship W2003103967A5032299448 @default.
• W2003103967 hasAuthorship W2003103967A5059371192 @default.
• W2003103967 hasAuthorship W2003103967A5070278395 @default.
• W2003103967 hasAuthorship W2003103967A5070365161 @default.
• W2003103967 hasAuthorship W2003103967A5072315367 @default.
• W2003103967 hasAuthorship W2003103967A5077441882 @default.
• W2003103967 hasAuthorship W2003103967A5080523158 @default.
• W2003103967 hasConcept C126322002 @default.
• W2003103967 hasConcept C142462285 @default.
• W2003103967 hasConcept C203014093 @default.
• W2003103967 hasConcept C2777182164 @default.
• W2003103967 hasConcept C2778414717 @default.
• W2003103967 hasConcept C2778715236 @default.
• W2003103967 hasConcept C2779298103 @default.
• W2003103967 hasConcept C2779778239 @default.
• W2003103967 hasConcept C2781432083 @default.
• W2003103967 hasConcept C2993143319 @default.
• W2003103967 hasConcept C3013748606 @default.
• W2003103967 hasConcept C71924100 @default.
• W2003103967 hasConceptScore W2003103967C126322002 @default.
• W2003103967 hasConceptScore W2003103967C142462285 @default.
• W2003103967 hasConceptScore W2003103967C203014093 @default.
• W2003103967 hasConceptScore W2003103967C2777182164 @default.
• W2003103967 hasConceptScore W2003103967C2778414717 @default.
• W2003103967 hasConceptScore W2003103967C2778715236 @default.
• W2003103967 hasConceptScore W2003103967C2779298103 @default.
• W2003103967 hasConceptScore W2003103967C2779778239 @default.
• W2003103967 hasConceptScore W2003103967C2781432083 @default.
• W2003103967 hasConceptScore W2003103967C2993143319 @default.
• W2003103967 hasConceptScore W2003103967C3013748606 @default.
• W2003103967 hasConceptScore W2003103967C71924100 @default.
• W2003103967 hasIssue "3" @default.
• W2003103967 hasLocation W20031039671 @default.
• W2003103967 hasLocation W20031039672 @default.
• W2003103967 hasOpenAccess W2003103967 @default.
• W2003103967 hasPrimaryLocation W20031039671 @default.
• W2003103967 hasRelatedWork W1988346372 @default.
• W2003103967 hasRelatedWork W2003103967 @default.
• W2003103967 hasRelatedWork W2029174775 @default.
• W2003103967 hasRelatedWork W2054491018 @default.
• W2003103967 hasRelatedWork W2096150279 @default.

• next