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- W2003105479 abstract "Anemia of inflammation (AI), also called anemia of chronic inflammation, occurs in a variety of disorders, including infections, chronic inflammation, and cancer. Recently, hepcidin, a disulfide-rich antimicrobial peptide homolog, has been identified as a central regulator of iron metabolism. For example, loss-of-function mutations of the hepcidin gene in mice or human beings induces hemochromatosis, whereas transgenic overexpression of hepcidin induces anemia. In this elegant study, the investigators combined murine and human experiments to provide evidence that IL-6 induces hepcidin and that this process is the main regulator of AI. They first demonstrate that anti–IL-6 inhibits production of hepcidin by primary human hepatocytes stimulated with LPS in vitro. They then demonstrate that IL-6 gene–targeted mice are protected from infection-induced hepcidin induction and, importantly, from the development of AI. Furthermore, they demonstrate that infusion of IL-6 into 6 healthy human subjects rapidly increased hepcidin levels and induced hypoferremia. Taken together, these results provide compelling evidence that the IL-6/hepcidin axis is the central regulator of anemia of chronic disease." @default.
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- W2003105479 date "2004-08-01" @default.
- W2003105479 modified "2023-09-25" @default.
- W2003105479 title "Mechanism of anemia of chronic disease elucidated" @default.
- W2003105479 doi "https://doi.org/10.1016/j.jaci.2004.06.006" @default.
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