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• W2003109370 abstract "To review the rationale supporting the use of levalbuterol [(R)-albuterol] for the treatment of pediatric and adult asthma.Peer-reviewed articles, selected abstracts from studies presented at recent professional meetings, and the Xopenex [levalbuterol, (R)-albuterol; Sepracor, Marlborough, MA] Summary Basis of Approval and package insert.Institutional review board-approved clinical study protocols.Levalbuterol is a single isomer beta2-agonist that differs from racemic albuterol by elimination of (S)-albuterol. Levalbuterol is an effective bronchodilator whose primary mechanism of action is unimpeded by (S)-albuterol. Thus, when compared with racemic albuterol, clinically comparable bronchodilation can be achieved with doses that substantially lessen beta-mediated side effects. In chronic or acute treatment of asthma, this favorable therapeutic profile cannot apparently be duplicated by increasing or decreasing the dose of racemic albuterol or by the addition of anticholinergic agents such as ipratropium bromide.Levalbuterol seems to provide efficacy and safety advantages in pediatric and adult patients suffering from asthma. Its use may afford a cost benefit as well. More clinical studies are required to extend these observations for use in the treatment of other pulmonary diseases in both adults and children and to determine levalbuterol's impact on long-term therapy of respiratory diseases." @default.
• W2003109370 created "2016-06-24" @default.
• W2003109370 creator A5078829922 @default.
• W2003109370 date "2003-06-01" @default.
• W2003109370 modified "2023-10-14" @default.
• W2003109370 title "Levalbuterol; pharmacologic properties and use in the treatment of pediatric and adult asthma" @default.
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• W2003109370 doi "https://doi.org/10.1016/s1081-1206(10)61859-5" @default.
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