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- W2003114917 abstract "Both plasma and adrenal tissue from two children with virilizing adrenal carcinoma were analyzed in order to determine their content of unconjugated steroids and of steroid sulfates. Plasma concentrations of pregnenolone. 17α-hydroxypregnenolone, dehydroepiandrosterone (DHA) and 5-androstene-3β. 17β diol were very high in both the unconjugated and the sulfate fractions. All of these compounds were isolated and quantitated in the tumor tissue. In both cases, uncon-jugated testosterone and testosterone sulfate levels were above normal in the plasma but in only one instance was unconjugated testosterone isolated from tumor tissue. In this child, the testosterone levels in the adrenal vein and in peripheral blood were similar suggesting that the circulating unconjugated testosterone was derived from peripheral conversion of precursor steroids. Small quantities of 7-keto DHA and loα-hydroxy DHA were isolated from the tumors both in the unconjugated form and as sulfates. Also isolated from the tumors were the following unconjugated steroids: progesterone, 17α-hydroxyprogesterone,4-androstene-3.17-dione, 11β-hydroxyandrostenedione, 11-deoxycortisol, corticosterone, cortisone and cortisol. The amounts present were small except for 11-deoxycortisol in one case and 11β-hydroxyandro-stenedione in the other, both being present in great quantity in the respective tumors. In both tumors the content of 5-en-3β-ol steroids was greater than that of 4-en-3-one compounds but the individual steroid patterns in the two cases were quite different." @default.
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- W2003114917 date "1974-06-01" @default.
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- W2003114917 title "2B. Steroid radioimmunoassay—I 32. Synthesis of 11α-C19-steroid-protein conjugates for new RIA antisera" @default.
- W2003114917 doi "https://doi.org/10.1016/0022-4731(74)90177-0" @default.
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