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- W2003114927 abstract "Abstract A precise, sensitive, repeatable and robust reverse-phase liquid chromatographic method has been developed for the control of seven possible impurities of diphenhydramine hydrochloride. The robustness of the method was examined by varying, in turn, each of four mobile-phase parameters (acetonitrile content, buffer salt concentration, ion-pair reagent concentration and pH). The method was linear in the range 0–0.14 mg mL−1 for diphenhydramine hydrochloride with an acceptable precision and accuracy, and a limit of detection of 0.17 μg mL−1. Five samples of diphenhydramine hydrochloride from two sources were analysed with the developed liquid chromatographic method." @default.
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- W2003114927 date "2001-03-01" @default.
- W2003114927 modified "2023-09-27" @default.
- W2003114927 title "Control of impurities in diphenhydramine hydrochloride by an ion-pairing, reverse-phase liquid chromatographic method" @default.
- W2003114927 doi "https://doi.org/10.1211/0022357011775550" @default.
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